林蛙皮抗菌肽研究进展

Study on Research Progress of Antibacterial Peptides

近年来外源性病原体的侵袭日益加重,急切需要从多种生物体中搜寻新的具有抗菌活性的药物,目前研究发现两栖类的生态类型多种多样且复杂多变,能够分泌出大量具有特殊结构、功能特殊的抗菌肽类物质,这种物质耐热性好、广谱抗菌活性强,能够为筛选抗菌药物提供重要研究信息。通过林蛙皮肤分泌物中的抗菌肽生物活性、抑菌机制、应用现状和研究价值等进行综述,为抗菌肽的深入研究提供重要的理论依据。

Recently, The invasion of exogenous pathogens is increasing, and it is urgent to search for new antibiotics with antibiotics from various organisms. At present, it has been found that the ecological types of amphibians are di- verse and complex, Structure, function of special antimicrobial peptides, this material is good heat resistance, broad spectrum antibacterial activity, can provide important research information for screening antibiotics. In this paper, the biological activity, antibacterial mechanism, application status and research value of antimicrobial peptides in skin exudates of Rana chensinensis were reviewed, which provided important theoretical basis for in-depth study of antimicrobial peptides.