宫颈、宫颈管、宫腔同时多中心性原发原位鳞癌一例及文献复习

The Cervix, Cervical Tube, Uterus and More Centricity Primary Squamous Carcinoma in Situ and Literature Review

目的:探讨宫颈、宫颈管、宫腔同时多中心性原发原位鳞癌的临床病理学特征、诊断和鉴别诊断、治疗及预后。方法:复习相关文献,对1例宫颈、宫颈管、宫腔同时多中心性原发原位鳞癌的临床资料、组织病理学特点、免疫表型及治疗预后进行分析。结果:患者宫颈、宫颈管、子宫内膜表面及子宫内膜息肉样病变表面均可见原位鳞癌,但彼此并不相连,免疫组化示宫颈及宫颈管原位鳞癌组织P63(+)、P40(+)、P53(+)、Ki67全层(+)、高分子质量细胞角蛋白(+)、P16胞质胞膜弥漫强阳性,但子宫内膜原位鳞癌P16(-)。结论:宫颈、宫颈管、子宫内膜同时多中心性原发原位鳞癌十分罕见,通过对其临床病理特征的认识,再结合相关检测,能够做到对该病的早期诊断、早期预防、提高生存率。

ObjectiveTo investigate the clinical pathologic characteristics, diagnosis, diferential diagnosis treatment and prognosis of at the same time more centricity primary squamous carcinoma in situ from the cervix, cervical tube and uterus. Methods ： One case of at the same time more centricity primary squamous carcinoma in situ from the cervix, cervical tube and uterus were analyzed by immunohistochemistry and morphology, and the related literatures were reviewed. Results ： Patients with cervix, cervical tube, uterine endometrium and endometrial polypoid lesion surface are visible in situ squamous cell carcinomas. But is not connected to each other. P63, P40, p53 and Ki67 are positive in squamous carcinoma tissues in situ of cervix and cervical tube, but P16 is negative in squamous carcinoma tissues in situ of uterine endometrium. Conclusions： At the same time more centricity primary squamous carcinoma in situ from the cervix, cervical tube and uterus are rare, understand its clinical pathological features of the diagnosis, differential diagnosis, treatment and prognosis of the disease is of great significance.