长脉宽Nd:YAG1064 nm激光治疗甲真菌病的疗效研究

Study on the Efficacy of Long Pulsed Nd:YAG 1064 nm Laser in the Treatment of Onychomycosis

目的研究长脉宽Nd:YAG 1 064 nm激光治疗甲真菌病的疗效。方法研究对象为2014年6月—2016年4月白色浅表型、全甲营养不良型或远端侧位甲下型甲真菌病患者44例,将其随机分两组。治疗组采用长脉宽Nd:YAG 1 064 nm激光治疗,对照组外用5%阿莫罗芬搽剂治疗。比较两组患者甲真菌病治疗总有效率、疗前和疗后患者SCIO评分的差异、不良反应发生率。结果激光治疗组患者甲真菌病治疗结束、疗后6个月的总有效率与5%阿莫罗芬搽剂组比较无明显差异,P>0.05;在治疗结束时、疗后6个月与治疗前相比,长脉冲Nd:YAG 1 064 nm激光组SCIO评分有显著差异;在治疗结束时、疗后6个月与治疗前相比,5%阿莫罗芬搽剂组SCIO评分亦有显著差异,均P<0.05。治疗过程中两组均未发生明显不良反应。结论长脉宽Nd:YAG1 064 nm激光治疗甲真菌病的疗效确切,与单用5%阿莫罗芬搽剂治疗效果相当,可有效改善患者病情,无明显不良反应,且疗程较外用5%阿莫罗芬搽剂缩短,值得推广应用。

Objective To study the efficacy of long pulsed Nd ： YAG 1 064 nm laser in the treatment of onychomycosis. Methods The research object for the June 2014 to 2016 year in April, the whole white superficial nail dystrophy or dlso patients in 44 cases, which were randomly divided into two groups. The treatment group with long pulse Nd： YAG 1 064 nm laser treatment, the control group were treated with 5% amorolfine liniment in treatment. Comparison of two groups of patients with onychomycosis treatment efficiency, differences in the incidence of treatment before and after treatment SCIO score in patients with adverse reactions. Results The laser therapy group after treatment, patients with onychomycosis 6 months after treatment the total effective rate of amorolfine liniment and no significant difference between group, P 〉 0. 05; compared to at the end of treatment, 6 months after treatment and before treatment, the score has significant difference of long pulsed Nd ： YAG 1 064 nm laser group than in the SCIO; at the end of treatment, 6 months after treatment and before treatment, 5% amorolfine liniment group SCIO scores were significant difference, P 〈 0. 05. No obvious adverse reactions occurred in the two groups during the treatment. Conclusion The efficacy of long pulsed Nd ： YAG 1 064 nm laser in the treatment of onychomycosis is exact, with 5% treatment effect of amorolfine liniment, can effectively improve the patient’s condition,no obvious adverse reactions, and course of 5% topical amorolfine liniment is shortened, it is worthy of popularization and application.