108例广东籍痛风石患者的临床特点和发病危险因素分析

Analysis of clinical features and risk factors of 108 patients with tophus from Guangdong Province

目的探讨广东籍痛风石患者的临床特点,分析发病危险因素。方法收集108例广东籍痛风石患者的临床资料,包括人口学资料、饮食习惯、病史、家族史、痛风石数目及合并症。建立多重线性回归模型分析痛风石发生的危险因素。结果 108例中男100例(92.5%)、女8例(7.5%),痛风石数目1~17(中位数1)个/人。痛风石所在关节以第1跖趾关节63例(30.4%)、膝关节46例(22.2%)、踝关节29例(14.0%)、足背24例(11.5%)及第2~5跖趾关节19例(9.1%)为主。痛风石数目与BMI(B=0.106,P=0.002)、血尿酸最高值(B=0.004,P=0.011)、高尿酸和痛风家族史(B=0.752,P=0.033)和肾结石(B=1.518,P<0.001)呈正相关,与生活规律呈负相关(B=-0.072,P=0.048)。结论广东籍痛风石患者以男性为主;痛风石所在关节以下肢多见;BMI越高,血尿酸值越高,有高尿酸和痛风家族史,有肾结石,生活无规律者的痛风石数目越多。

Objective To investigate the clinical characteristics and risk factors of tophaceous gout patients from Guangdong province, China. Methods Clinical data including demographic data, dietary habit, medical history, family history, quantity of tophaceous gout and complications of 108 patients diagnosed with tophaceous gout in Guangdong province were collected. Multiple linear regression model was established to ana-lyze the risk factors of the incidence of tophaceous gout. Results Among 108 patients, 100 （ 9 2 .5% ） were male and 8 （7. 5% ） female. The quantity of tophaceous gout for each patient ranged from 1 to 17. The tophac-eous gout was observed in the first metatarsophalangeal joint of 63 cases （ 30. 4% ） , knee joint of 46 （22. 2% ） , ankle joint of 29 （14. 0% ） , foot dorsum of 24 （11.5%）, and the second to fifth metatarsophalan-geal joints of 19 （9. 1% ）. The quantity of tophaceous gout was positively correlated with BMI （B = 0. 106, P =0. 002） the peak value of serum uric acid （B = 0. 004 ,P = 0.011 ） family history of hyperuricemia and gout （ B = 0. 752, P=0.033） and renal calculi （B = 1.518, P〈0.001）, and negatively correlated with life style （B = -0. 072 , P = 0. 048 ） . Conclusions A majority of the tophaceous gout patients in Guangdong Province are male. Tophaceous gout is mainly observed in the lower limb. The quantity of tophaceous gout is increased in patients with higher BMI,higher level of serum uric acid, family history of hyperuricemia and gout, renal calculi and irregular life style.