温阳通脉方联合氯吡格雷治疗不稳定型心绞痛临床观察

Clinical observation of Wenyang Tongmai decoction combined with clopidogrel in the treatment of unstable angina pectoris

目的:探究温阳通脉方联合氯吡格雷治疗不稳定型心绞痛的临床疗效。方法:选取不稳定型心绞痛患者100例,采取随机数字表法分为对照组和治疗组,各50例。对照组采用硫酸氢氯吡格雷片治疗,治疗组在此基础上加服温阳通脉方,疗程为8周。治疗8周后,观察两组患者心绞痛发作次数、持续时间及硝酸甘油日耗量,及血清超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)水平情况。结果:两组心绞痛发作频率,持续时间,硝酸甘油的消耗量比较,差异具有统计学意义(P<0.05)。治疗后治疗组患者血清hs-CRP、IL-6水平高于对照组(P<0.05);治疗组与对照组的总有效率为92.00%、78.00%。结论:温阳通脉方联合氯吡格雷能够使患者心绞痛发作频率减少、持续时间缩短,疗效显著。

Objective To explore the clinical curative effect of Wenyang Tongmai decoction combined withclopidogrel in the treatment of unstable angina pectoris. Methods： 100 cases of patients with unstable type , the pa-tients were randomly divided into control group and experimental group. Two group with 50 cases in each group. The control group using clopidogrel bisulfate tablets for treatment, the experimental group added sis of Wenyang Tongmai decoction for the treatment of 8 weeks. After treatment with angina attacked frequency,duration and consumption of nitroglycerin, high sensitivserum -6 level were observed. Results： Two groups of patients with angina attack frequency, duration, nitroglycerin consumption comparison, the difference was statistically significant （P〈0. 05）. The experimental group after treat-ment serum hs-CRP, IL-6 levels higher than the control group （P〈0. 05）. The total effective rate of patients in the experimental group and the control group were 92. 00% , 78. 00%. Conclusion： Wenyang Tongmai decoction com-bined with clopidogrel in patients with angina pectoris can reduce seizure frequency, duratiosigniiicamt clinical value.