抗中性粒细胞胞浆抗体相关性小血管炎临床病理特征及治疗的研究进展

Progress on Clinicopathologic Features and Treatment of Antineutrophil Cytoplasmic Antibody Associated Systemic Vasculitis

抗中性粒细胞胞浆抗体相关性小血管炎(AASV)是一组以小血管壁炎症和/或纤维素样坏死为主要病理特征的自身免疫性疾病,目前我国AASV发病率不详,但其在临床上并不少见。AASV的病理变化复杂,可累及全身血管及器官,因此其临床表现缺乏特异性。根据肾小球受累程度可将AASV所致肾损伤分为局灶型、新月体型、混合型及硬化型,而AASV的治疗主要包括诱导缓解治疗、维持缓解治疗及复发的治疗,其中诱导缓解治疗是临床治疗AASV的关键。近年来关于AASV的研究报道较多,本文对AASV临床病理特征及治疗的研究进展进行综述。

Antineutrophil cytoplasmic antibodiy associated systemic vasculitis(AASV) is one kind of autoimmune diseases,with small vascular wall inflammation and/or fibrinoid necrosis as the pathological features. Morbidity of AASV is not quite clear in China so far,but it is not uncommon on clinic. Pathological change of AASV is complex,may involve whole body vessels and organs,so the clinical manifestations are lack of specificity. According to the degree of glomerular injury,AASV-induced renal damage are roughly divided into focal type,crescentic type,mixed type and sclerotic type. Treatment for AASV includes remission induction therapy,maintenance remission therapy and relapse treatment,thereinto induction remission therapy is the key of clinical treatment for AASV. In recent years, reports about AASV is common, this paper reviewed the clinicopathologic features and treatment of AASV.