血清羧化不全骨钙素水平与2型糖尿病患者心血管危险因素的关系研究

Relationship between Serum Under-carboxylated Osteocalcin Level and Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus

目的分析血清羧化不全骨钙素水平与2型糖尿病患者心血管危险因素的关系。方法选择2013—2016年榆林市第一医院绥德医院收治的2型糖尿病患者250例作为研究组,选取同期体检健康者300例作为对照组。比较两组受试者一般资料和生化检查指标,血清羧化不全骨钙素与2型糖尿病患者心血管危险因素的相关性分析采用Pearson相关性分析。结果两组受试者身高、体质量、体质指数(BMI)、体脂率及体力活动不足者所占比例比较,差异均无统计学意义(P>0.05);研究组患者腰围、腰臀比大于对照组,收缩压、舒张压、吸烟率和饮酒率高于对照组(P<0.05)。研究组患者血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、LDL/高密度脂蛋白(HDL)、TC/HDL、极低密度脂蛋白(VLDL)、空腹血糖(FPG)、空腹胰岛素(FINS)水平及胰岛素抵抗指数(HOMA-IR)高于对照组,血清HDL和羟化不全骨钙素水平低于对照组(P<0.05);两组受试者血清超敏C反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05)。Pearson相关性分析结果显示,血清羧化不全骨钙素水平与2型糖尿病患者BMI(r=-0.303)、体脂率(r=-0.307)呈负相关,与舒张压(r=0.448)呈正相关(P<0.05)。结论血清羧化不全骨钙素水平与2型糖尿病患者BMI、体脂率及舒张压有关。

Objective To analyze the relationship between serum under-carboxylated osteocalcin level and cardiovascular risk factors in patients with type 2 diabetes mellitus. Methods From 2013 to 2016 in Suide Hospital of the First Hospital of Yulin,a total of 250 patients with type 2 diabetes mellitus were selected as study group,300 healthy people admitted to this hospital for physical examination were selected as control group. General information and biochemical examination results were compared between the two groups,and Pearson correlation analysis was used to analyze the relationship between serum under-carboxylated osteocalcin level and cardiovascular risk factors in patients with type 2 diabetes mellitus. Results No statistically significant differences of height,weight,BMI,body fat percentage or proportion of patients with poor physical activity was found between the two groups(P > 0. 05); waistline and WHR of study group were statistically significantly larger than those of control group,SBP,DBP,smoking rate and drinking rate of study group were statistically significantly higher than those of control group(P < 0. 05). Serum levels of TC,TG,LDL,LDL/HDL,TC/HDL,VLDL,FPG and FINS,and HOMA-IR of study group were statistically significantly higher than those of control group,while serum levels of HDL and under-carboxylated osteocalcin of study group were statistically significantly lower than those of control group(P < 0. 05); no statistically significant differences of serum hs-CRP level was found between the two groups(P > 0. 05). Pearson correlation analysis results showed that,serum under-carboxylated osteocalcin level was negatively correlated with BMI(r =-0. 303) and body fat percentage(r =-0. 307),respectively,was positively correlated with DBP(r = 0. 448) in patients with type 2 diabetes mellitus(P < 0. 05).Conclusion Serum under-carboxylated osteocalcin level is closely correlated with BMI, body fat percentage and DBP in patients with type 2 diabetes mellitus,respectively.