沙美特罗替卡松粉吸入剂联合穴位药物注射疗法治疗非急性发作期支气管哮喘的临床疗效及其对患者生活质量的影响

Clinical Effect of Salmeterol Assigned Powder Inhaler Combined with Acupoint Injection Therapy on Non Acute Attack of Bronchial Asthma and the Impact on Quality of Life

目的观察沙美特罗替卡松粉吸入剂联合穴位药物注射疗法治疗非急性发作期支气管哮喘的临床疗效,并探讨其对患者生活质量的影响。方法选取2014—2015年唐山市人民医院收治的非急性发作期支气管哮喘患者102例,随机分为对照组50例和观察组52例。对照组患者给予沙美特罗替卡松粉吸入剂治疗,观察组患者在对照组基础上给予穴位药物注射疗法;两组患者均连续治疗5个月。比较两组患者临床疗效,治疗前后哮喘控制问卷(ACT)评分、圣·乔治呼吸问卷(SGRQ)评分、肺功能指标[包括第1秒用力呼气容积(FEV_1)、最大呼气流量(PEF)],观察两组患者治疗期间不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。两组患者治疗前ACT评分、SGRQ评分比较,差异无统计学意义(P>0.05);治疗后观察组患者ACT评分高于对照组,SGRQ评分低于对照组(P<0.05)。两组患者治疗后ACT评分高于治疗前,SGRQ评分低于治疗前(P<0.05)。两组患者治疗前FEV_1、PEF比较,差异无统计学意义(P>0.05);治疗后观察组患者FEV_1、PEF高于对照组(P<0.05)。两组患者治疗后FEV_1、PEF高于治疗前(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论沙美特罗替卡松粉吸入剂联合穴位药物注射疗法治疗非急性发作期支气管哮喘的临床疗效确切,能有效改善患者肺功能,提高患者生活质量,且安全性较高。

Objective To observe the clinical effect of salmeterol assigned powder inhaler combined with acupoint injection therapy on non acute attack of bronchial asthma,to investigate the impact on quality of life. Methods A total 102 patients with non acute attack of bronchial asthma were selected in the People's Hospital of Tangshan from 2014 to 2015,and they were randomly divided into control group(n = 50) and observation grop(n = 52). Patients of control group received salmeterol assigned powder inhaler,while patients of observation group received salmeterol assigned powder inhaler combined with acupoint injection therapy; both groups continuously treated for 5 months. Clinical effect, ACT score, SGRQ score and index of pulmonary function(including FEV_1 and PEF) before and after treatment were compared between the two groups,and incidence of adverse reactions was observed during the treatment. Results Clinical effect of observation group was statistically significantly better than that of control group(P < 0. 05). No statistically significant differences of ACT score or SGRQ score was found between the two groups before treatment(P > 0. 05); after treatment, ACT score of observation group was statistically significantly higher than that of control group,while SGRQ score of observation group was statistically significantly lower than that of control group(P < 0. 05). After treatment,ACT score of the two groups was statistically significantly higher than that before treatment,respectively,while SGRQ score of the two groups was statistically significantly lower than that before treatment,respectively(P < 0. 05). No statistically significant differences of FEV_1 or PEF was found between the two groups before treatment(P > 0. 05),while FEV_1 and PEF of observation group were statistically significantly higher than those of control group after treatment(P < 0. 05). After treatmet,FEV_1 and PEF of the two groups were statistically significantly higher than those before treatment(P < 0. 05). No statistically significant differences of incidence of adverse reactions was found between the two groups during the treatment(P > 0. 05). Conclusion Salmeterol assigned powder inhaler combined with acupoint injection therapy has certain clinical effect in treating patients with non acute attack of bronchial asthma, can effectively improve the pulmonary function and quality of life,with relatively high safety.