组蛋白乙酰化修饰异常与阿尔兹海默病

Abnormal modification of histone acetylation in Alzheimer's disease

阿尔兹海默病(Alzheimer's disease,AD)是一种以老年斑和神经纤维缠结为病理特征的慢性中枢性神经系统退行性疾病。在DNA编码序列不变的情况下,通过影响基因转录活性(如DNA可接触性、转录因子及调节因子的酶活性等)调控基因表达水平的表观遗传调控在疾病发生中的作用越来越受到重视。研究显示,表观遗传调控在AD病理机制中起重要作用,其中组蛋白乙酰化修饰异常可能与AD发生发展密切相关。现结合组蛋白乙酰化/去乙酰化的发生过程机制,概述组蛋白乙酰化修饰与AD发病机制相关的研究进展。

Alzheimer’s disease（AD） is a chronic central nervous system degenerative disease, which is characterized by senile plaques and neurofibrillary tangles, and the pathogenesis on AD development is very complex. The epigenetic regulation means that, under the condition of the same DNA coding sequence, the expression level of a gene is regulated by the transcriptional activity including DNA accessibility and activities of the transcriptional or regulatory factors. Researchers have paid attention to the epigenetic regulation on the occurrence of a disease. Epigenetic modifications including histone acetylation have been implicated in AD pathogenesis. Based on the mechanism of the modification on histone acetylation/deacetylation, this review summarizes the research progress of histone acetylation modification in AD pathogenesis.