雄激素受体在乳腺癌中的研究进展

Progression on androgen receptor in breast cancer

大约70%的乳腺癌表达雄激素受体(androgen receptor,AR),研究数据表明雄激素受体可能在乳腺癌的发生机制中起重要作用,在某些难治性乳腺癌亚型中可以作为一种治疗靶点,比如三阴性乳腺癌(Triple-Negative Breast Cancer,TNBC)。临床上AR作为预后标志物及其在肿瘤中的功能作用尚不完全清楚。目前,乳腺癌中AR的研究已成为一个新的热点,本文就AR在乳腺癌中的研究现状作一综述。

About 70% of human breast cancers express androgen receptor（AR）. Studies suggest that AR may play a role in pathogenesis of breast cancer and serve as a therapeutic target in certain types of breast cancer, such as triple-negative breast cancer（TNBC）. Although this is an active research area, the clinical significance of AR as a prognostic marker and its role in tumorigenesis is unclear yet. At present, the research of AR in breast cancer becomes a new hotspot. This article reviews the research progress of the relationship between AR and breast cancer.