乳腺癌缺失基因1作用的研究进展

Research progress on roles of DBC1 gene in various diseases

DBC1最早发现是在乳腺癌中杂合性缺失,被称为乳腺癌缺失基因1(deleted in breast cancer 1)。DBC1在基因表达、细胞周期及凋亡、肿瘤发生等过程中均有不同的调节作用。随着研究的不断深入,对DBC1的表达进行调控很可能成为肿瘤,炎症以及代谢性疾病重要的干预靶点。本文对DBC1在肿瘤、淋巴细胞功能和部分代谢性疾病中的作用进行综述。

Deleted in breast cancer 1 （DBC1） gene was first found to be heterozygous for deletion in breast cancer. Recent studies have demonstrated that DBC1 plays different roles in gene expression, cell cycle, apoptosis and tumor occurrence. Therefore, it may be a therapeutic target for cancer, inflammation and metabolic diseases. This review summarized the roles of DBC1 in tumor progression, lymphocytes function and some metabolic diseases.