摘要
The DMAP-catalyzed [4+2] cycloaddition of α,β-unsaturated carboxylic acids with ketones furnishing α,β-unsaturated δ-lactones in good yields (up to 80%) is described, which is the first example of remote -C(sp^3)-H activation of α,β-unsaturated carboxylic acids facilitated by DMAP, a pyridine-based catalyst.
The DMAP-catalyzed [4+2] cycloaddition of α,β-unsaturated carboxylic acids with ketones furnishing α,β-unsaturated δ-lactones in good yields (up to 80%) is described, which is the first example of remote -C(sp^3)-H activation of α,β-unsaturated carboxylic acids facilitated by DMAP, a pyridine-based catalyst.
基金
This work is supported by the National Natural Science Foundation of China (No. 21372074).