清肝利胆胶囊联合左氧氟沙星治疗肝胆湿热型慢性胆囊炎临床疗效观察

The clinical efficacy of Qingganlidan capsules combined with levofloxacin in cholecystitis

目的:观察清肝利胆胶囊联合左氧氟沙星治疗肝胆湿热型慢性胆囊炎的临床疗效。方法:纳入2014年5月至2015年5月我院收治的中医症候为肝胆湿热型的慢性胆囊炎患者98例,按随机数字表法分为观察组49例和对照组49例。对照组给予左氧氟沙星治疗,观察组患者在对照组基础上加用清肝利胆胶囊联合治疗。记录并分析两组患者治疗前和治疗后中医症候积分变化、肿瘤坏死因子(TNF-α)、β-内啡呔(β-EP)、白细胞(WBC)、血清丙二醛(MDA)和血清超氧化歧化酶(SOD)水平的变化、胆囊B超疗效和临床疗效。结果:观察组治疗后中医症状积分为(6.73±2.07)分,显著低于对照组(10.02±2.33)分。观察组治疗后TNF-α、β-EP和WBC水平分别为(0.8±0.1ng/ml、150.1±10.4pg/ml、7.11±0.36×109/L),均明显低于对照组(1.1±0.1ng/ml、170.0±13.2pg/ml、8.14±0.47×109/L)。观察组治疗后MDA和SOD水平分别为(13.1±0.5nmol/ml、682.1±35.7ng/ml),均明显优于对照组(14.9±0.8nmol/ml、608.9±32.5ng/ml);4观察组治疗后胆囊B超疗效总有效率为81.63%,显著高于对照组59.18%。5观察组治疗后临床疗效总有效率为85.71%,显著高于对照组61.22%。6治疗后观察组胆壁增厚、胆囊壁毛糙、胆囊体积变形和患者比例分别为(20.41%、22.45%、12.24%),均明显低于对照组(42.86%、46.94%、30.61%)。结论:清肝利胆胶囊联合左氧氟沙星可有效降低肝胆湿热型慢性胆囊炎患者体内炎症水平,调节体内相关因子水平,提高慢性胆囊炎的治疗效果。

Objective： To observe the clinical efficacy of Qingganlidan Capsules combined with levofloxacin in cholecystitis.Methods： 99 patients with cholecystitis from May 2014 to-May 2015 were randomly divided into observation group with 49 cases and control group with 50 cases.The control group received levofloxacin,and the observation group received Qingganlidan capsules combined with levofloxacin.Indexes of patients before and after treatment were measured.Results： 1TCM symptom score of observation group after treatment was（ 6.73 ± 2.07）points,lower than that of the control group（ 10.02 ± 2.33） points,and the difference was significant（ P 〈 0.05）.2TNF-α,β-EP and WBC levels of observation group after treatment were（ 0.8 ± 0.1ng/ml,150.1 ± 10.4pg/ml,7.11 ± 0.36 × 109/L） respectively,lower than that of the control group（ 1.1 ± 0.1ng/ml,170.0 ± 13.2pg/ml,8.14 ± 0.47 × 109/L）,and the differences all were statistically significant（ P 〈 0.05）.3MDA and SOD of observation group after treatment were（ 13.1 ± 0.5nmol/ml,682.1 ± 35.7ng/ml） respectively,better than that of the control group（ 14.9 ± 0.8nmol/ml,608.9 ± 32.5ng/ml）,and the differences are significant（ P 〈 0.05）.4After treatment,B-gallbladder total effective rate of observation group was 81.63%,higher than that of the control group 59.18%,and the difference was significant（ P 〈 0.05）.5The total effective rate of observation group was 85.71%,higher than that of the control group 61.22%,and the difference was significant（ P 〈 0.05）.6Proportion of gallbladder wall thickening,gallbladder wall rough and volume deformation of gallbladder of observation group were（ 20.41%,22.45%,12.24%） respectively,lower than that of the control group（ 42.86%,46.94%,30.61%）,and the differences were significant（ P 〈 0.05）.Conclusion： Qingganlidan capsules combined with levofloxacin can effectively reduce inflammation,regulate correlation factors levels.We think that it is an effective treatment program.