101例藿香正气水药品不良反应文献分析

Literature Analysis of 101 Cases of Adverse Reactions Induced by Huoxiangzhengqi Liquid

目的研究藿香正气水致药品不良反应(ADR)的规律和特点,为临床合理用药提供参考。方法以"藿香正气水"、"不良反应"、"致"、"引起"、"副作用"为检索词,检索中国期刊网全文数据库,通过文献追溯法对涉及藿香止气水ADR的文献资料进行提取与统计分析。结果按纳入与排除标准共纳入33篇文献,提取病例101例。ADR多数出现在中青年人群,原患疾病主要为急性胃肠炎,85.15%的ADR在1 h内发生,累及系统主要为全身性损害、神经和精神系统损害、心血管系统损害和皮肤及附件损害等,其中以全身性损害最为常见,主要包括潮红、过敏性休克、双硫仑样反应、过敏样反应等。结论应加强藿香正气水的临床合理使用,注意ADR,进一步完善药品说明书。

Objective Through investigating the characteristics and mechanism of adverse drug reactions （ADR） induced by Huoxiangzhengqi liquid, to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods The keywords ＂Huoxiangzhengqi liquid＂, ＂adverse reaction＂, ＂side effect＂ and ＂induced＂ were used to search and retrieve articles in the CNKI database to extract and analyze literature data about Huoxiangzhengqi liquid. Results 33 references met the inclusion and exclusion criteria which including 101 cases. The ADRs mainly occur red in the middle and young individuals. The primary diseases were acute gastroenteritis. 85.15% of ADRs happened in 1 h after administration. Systems and organs mainly involved in ADRs were systematic disorders, neurological and psychiatric system disorders, cardiovascular system disorders, skin and its appendages disorders, etc. The systematic disorders were the most common reported ADRs, including red hot, anaphylactic shock, double sulfur shimron reaction, anaphylactoid reaction, etc. Concl0sion It is important to pay attention to the ADRs caused by Huoxiangzhengqi liquid, strengthen clinical rational use of drugs, and improve the medical instructions