越鞠丸改良配方治疗乳腺癌术后化疗致胃肠道反应的临床疗效

Clinical effect of yueju pills improved formula on gastrointestinal reaction cased by breast cancer postoperative chemotherapy

目的探讨越鞠丸改良配方治疗乳腺癌术后化疗致胃肠道反应的临床疗效。方法选取泸州医学附属中医医院乳腺外科2015年4月—2016年7月收治的乳腺癌术后化疗致胃肠道反应患者100例,随机分为对照组和研究组,各50例。对照组患者给予麻仁丸治疗,研究组患者给予越鞠丸改良方治疗,两组患者均持续治疗2个月。比较两组患者临床疗效及治疗前、治疗后2个月血清指标[5-羟色胺(5-HT)、血清P物质(SP)、神经激肽1受体(NK1)],观察两组患者不良反应发生情况。结果研究组患者总有效率高于对照组(P<0.05)。治疗前,两组患者5-HT、SP和NK1水平比较,差异无统计学意义(P>0.05);治疗后2个月,研究组患者5-HT、SP水平低于对照组,NK1水平高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用越鞠丸改良方治疗乳腺癌术后化疗致胃肠道反应的临床疗效确切,可有效缓解患者胃肠道反应,改善胃肠功能,且安全可靠。

Objective To analyze the clinical effect of Yueju pills improved formula on gastrointestinal reaction cased by breast cancer postoperative chemotherapy.Methods A total of 100 cases of gastrointestinal reaction patients cased by breast cancer postoperative chemotherapy were selected from April 2015 to July 2016 in Luzhou Medical Affiliated TCM Hospital,which were randomly divided into control group and study group,50 cases in each group.Control group was taken with maren pills,and study group was taken with yueju pills improved formula,both groups were treated for 2 months.The clinical effect,serum indices（5-HT,SP,NK1） before and after the treatment of 2 months were compared between the two groups,and the incidence of adverse reactions were observed.Results The total efficiency rate of study group was higher than control group（P〈0.05）.Before treatment,no statistically significant differences of 5-HT,SP or NK1 was found between the two groups（P〉0.05）;after the treatment of 2 months,the study group of 5-HT,SP were lower than control group,NK1 was higher than control group（P〈0.05）.No statistically significant difference of the incidence of adverse reactions was found between the two groups（P〉0.05）.Conclusion Yueju pills improved formula has an obviously clinical effect on gastrointestinal reaction cased by breast cancer postoperative chemotherapy,it can effectively relife the gastrointestinal reaction,improve the gastrointestinal function,and with good safety.