盐酸多奈哌齐治疗老年痴呆症的临床疗效

Clinical effect of donepezil hydrochloride in treating senile dementia

目的探讨盐酸多奈哌齐治疗老年痴呆症的临床疗效。方法选取成都市第四人民医院2011—2013年收治的老年痴呆症患者132例,根据治疗药物的不同分为对照组(n=56)和治疗组(n=76)。对照组患者采用常规对症治疗,治疗组患者在对照组基础上给予盐酸多奈哌齐治疗,两组患者均持续治疗6周。随访2年,比较两组患者治疗前后日常生活能力量表(ADL)评分及简易精神状况检查量表(MMSE)评分,并观察两组患者不良反应发生情况。结果治疗前及治疗后3个月,两组患者ADL评分和MMSE评分比较,差异无统计学意义(P>0.05);治疗后2年,治疗组患者ADL评分、MMSE评分高于对照组(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用盐酸多奈哌齐治疗老年痴呆症的临床疗效确切,可有效提高患者远期效果,且安全性好。

Objective To investigate the clinical effect of donepezil hydrochloride in treating senile dementia.Methods A total of 132 cases of senile dementia patients were selected from 2011 to 2013 year in the Fourth People＆#39;s Hospital of Chengdu,which were divided into control group（n=56） and treatment group（n=76） according to different medicine treatments.Control group was given basic treatment,treatment group was treated with donepezil hydrochloride on the basis of control group.Followed-up 2 years,the ADL scores and MMSE scores before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed of the two groups.Results There was no significant difference in ADL score and MMSE score between the two groups before and after treatment of 3 months（P〉0.05）.After treatment of 2 years,ADL score and MMSE score in the treatment group were higher than those in the control group （P〈0.05）.There was no significant difference in the incidence of adverse reactions between the two groups （P〉0.05）.Conclusion Donepezil hydrochloride has an obviously clinical effect in the treatment of senile dementia,it is helpful to improve the long-term effect,and with good safety.