陕西省安康地区女性人群人乳头瘤病毒感染状况及亚型分布特征

Infection status of human papillomavirus and distribution characteristics of human papillomavirus subtypes among female population in Ankang region of Shaanxi province

目的探讨陕西省安康地区女性人群宫颈人乳头瘤病毒(HPV)感染亚型的分布特征。方法选择安康市中心医院9 006例女性,采用PCR导流杂交技术对HPV感染亚型进行分型检测,分析HPV感染亚型分布特征及各年龄段女性人群HPV感染状况。结果 9 006例女性中共检出HPV阳性1 957例,HPV感染总阳性率为21.73%。高危HPV亚型在各年龄段女性中均有较高的感染率,>60岁年龄组最高,41~50岁年龄组最低,各年龄组比较差异均有统计学意义(P<0.05)。各年龄段女性人群均以高危HPV亚型感染为主,低危亚型和高低危亚型混合感染率均较低,其变化曲线略呈低"V"字形。2 175例高危HPV感染女性中,单一感染和多重感染女性分别为1 306例和869例;377例低危HPV感染女性中,单一感染和多重感染女性分别为211例和166例。高危HPV感染较常见的亚型均依次为HPV16、HPV58、HPV52、HPV53、HPV39和HPV33,分别占单一和多重高危感染的78.94%(1 031/1 306)和75.08%(1 633/2 175);在低危HPV感染中,较常见的亚型均为HPV81、HPV11和HPV6,分别占单一和多重低危感染的95.73%(202/211)和93.90%(354/377)。最常见的单一和多重感染亚型分别为HPV16和HPV81。不同年龄段女性人群最常见的高危HPV感染亚型为HPV16。在不同年龄段女性人群中,均以单一感染为主。在多重感染中,二重感染最多见。结论陕西省安康地区女性人群HPV感染率较高,常见高危亚型为HPV16、HPV58、HPV52、HPV53、HPV39、HPV33,低危亚型为HPV81和HPV11。不同年龄段女性HPV感染亚型分布不同。不同年龄段女性高危和高低危HPV亚型混合感染率有显著差异。

Objective To explore the distribution characteristics of human papillomavirus （HPV） subtypes among female population in Ankang region of Shaanxi province. Methods A total of 9 006 women were selected from Ankang Municipal Central Hospital, PCR flow-through hybridization technique was used to conduct genotyping of HPV subtypes, the distribution characteristics of HPV subtypes and HPV infection status among female population in different age groups were analyzed. Results Among 9 006 women, 1 957 women were found with positive HPV, the total positive rate of HPV infection was 21.73%. The infection rates of high-risk HPV genotypes among the women in different age groups were relatively high. The infection rates of high-risk HPV genotypes in women more than 60 years old was the highest, and the infection rates of high-risk HPV genotypes in women aged 41-50 years old was the lowest, there was statistically significant difference among different age groups （ P〈0. 05 ） . High-risk HPV genotypes infection was the main infection type of HPV among the women in different age groups. The mixed infection rates of low-risk HPV genotypes and low-risk HPV genotypes combined with high-risk HPV genotypes were relatively low, the change curve showed ＂V＂ shape. Among 2 175 women with high-risk HPV infection, 1 306 women with single HPV infection and 869 women with muhiple HPV infection were found; among 377 women with low-risk HPV infection, 211 women with single HPV infection and 166 women with multiple HPV infection were found. The common high-risk HPV infection genotypes were HPV16, HPV58, HPV52, HPV53, HPV39, and HPV33, which accounted for 78.94% （1 031/1 306） and 75.08% （1 633/2 175） of single HPV infection and multiple HPV infection, respectively. The common low-risk HPV infection genotypes were HPV81, HPVll, and HPV6, which accounted for 95.73 % （202/211 ） and 93.90% （354/377） of single HPV infection and multiple HPV infection, respective- ly. The most common single HPV infection genotype and multiple HPV infection genotype were HPV16 and HPV81, respectively. The most common high-risk HPV infection genotype among the women in different age groups was HPV16. Among the women in different age groups, single HPV infection was the main type. Among the women with multiple infection, double irrfection was the main type. Conclusion HPV infection rate among the women in Ankang region of Shaanxi province is relatively high, the common high-risk HPV infection genotypes are HPV16, HPV58, HPV52, HPV53, HPV39, HPV33; the common low-risk HPV infection genotypes are HPVS1 and HPV11. The distributions of HPV infection genotypes among the women in different age groups are different. There are statistically significant differences in high- risk HPV infection and high-low-risk mixed HPV infection rates among the women in different age groups.