摘要
目的探讨辅助性T细胞17(Th17)和调节性T细胞(Treg)在子宫内膜癌中的表达及意义。方法将上海市第一人民医院宝山分院2014-2015年收治的30例子宫内膜癌患者列为研究组,38例子宫肌瘤患者列为对照组。应用免疫组织化学染色法,分别检测两组患者标本Th17和Treg细胞表达情况。结果研究组Th17和Treg的表达较对照组明显升高(P<0.05),研究组中,进展期、中低分化组Th17和Treg表达显著高于早期、高分化组,差异有统计学意义(P<0.05),Th17和Treg之间有关联,但在子宫内膜癌进展期关联性差。结论 Th17和Treg参与子宫内膜癌的发生发展,随着肿瘤进展,Treg/Th17存在失衡现象。
Objective To explore the expressions and significance of helper T cell 17（ Th17） and regulatory T cell（ Treg） in endometrial carcinoma. Methods Thirty patients with endometrial carcinoma treated in the hopsital from 2014 to 2015 were selected as study group,and 38 patients with uterine fibroids treated in the hospital during the same period were selected as control group. Immunohistochemistry assay was used to detect the expressions of Th17 and Treg in the two groups. Results The expressions of Th17 and Treg in study group were statistically significantly higher than those in control group（ P〈0. 05）. In study group,the expressions of Th17 and Treg in progressive stage group and moderate or poor differentiation group were statistically significantly higher than those in early stage group and high differentiation group（ P〈0. 05）. Th17 was correlated with Treg,but the correlation in endometrial carcinoma at progressive stage was poor. Conclusion Th17 and Treg participate in the oncogenesis and development of endometrial carcinoma,the imbalance of Treg/Th17 occurs with aggravation of the disease.
出处
《中国妇幼保健》
CAS
2017年第11期2304-2306,共3页
Maternal and Child Health Care of China
基金
上海市宝山区2013年科技计划项目(13-E-12)
