IL-10基因T-819C多态性位点与自发性早产遗传易感性的病例对照研究

A case-control study on the polymorphism at the T-819C locus of IL-10 gene and genetic susceptibility to spontaneous preterm birth

【目的】探讨IL-10基因T-819G位点与自发性早产遗传易感性的关联性。【方法】病例组样本包括569例SPTB新生儿,对照组包括673例足月新生儿。采用最新的Sequenom Mass ARRAY?SNP检测技术对IL-10基因T-819C位点进行单核苷酸多态性分型。【结果】与携带IL-10基因T-819C位点的TT基因型的个体相比,携带至少一个C等位基因型(TC+CC基因型)的个体发生极早产的风险显著升高。【结论】在中国人群中,IL-10基因T-819G位点与极早产患病风险的增加存在显著的遗传学关联。

【Objective】 To explore the correlation between the genetic polymorphism at the T-819 C locus of IL-10 gene and susceptibility to spontaneous preterm birth（SPTB）.【Methods】There were 569 SPTB neonates in the case group and 673 term neonates in the control group.The single nucleotide polymorphism was genotyped at the T-819 C locus of IL-10 gene by Sequenom Mass ARRAY？SNP.【Results】Compared with the TT genotype,the IL-10T-819 C C-positive genotype（TC＋CC genotype） was significantly associated with an increased susceptibility to extreme preterm birth.【Conclusion】Among the Chinese population,IL-10T-819 C polymorphism is significantly associated with genetic susceptibility to extreme preterm birth.