三叶荚蒾中萜类化学成分的研究

Terpenoids isolated from Viburnum ternatum

采用硅胶、反向硅胶、Sephadex LH-20及MCI柱色谱等多种色谱技术和方法对三叶荚蒾Viburnum ternatum进行化学成分研究,运用现代波谱学方法并结合文献对分离得到的化合物进行结构鉴定。从该植物枝叶70%丙酮水提取液的醋酸乙酯萃取部分中分离并鉴定了12个化合物,包括4个环烯醚萜类成分ternatumin A(1),2,9-dioxatricyclo[4.3.1.03,7]decanes(2),7,10,2'-triacetylsuspensolide F(3)和7,10,2',3'-tetra-acetylsuspensolide F(4),5个环烯醚萜苷类成分viburtinoside IV(5),viburtinoside II(6),viburtinoside B(7),luzonoside A(8)和luzonoside B(9)以及3个三萜类成分2α,3β,24-trihydroxy-12-ursen-28-oic acid(10),6-hydroxy-20(29)-lupen-3-one(11)和pomalic acid(12)。其中,化合物1为新化合物,化合物2为新天然产物,化合物3~12为首次从该植物中分离得到。

Four iridoids （14）, five iridoid glucosides （5-9）, and three triterpenoids （10-12） were isolated from the ethyl acetate soluble fraction of 70% Me, CO extract of the aerial parts of Viburnum ternatum through various column chromatographies over silica gel, ODS, Sephadex LH-20 and MCI. Their structures were elucidated as ternatumin A （ 1 ）, 2,9-dioxatricyclo [ 4. 3. 1.03,7 ] decanes （2）, 7,10,2＇-triacetylsuspensolide F （ 3 ）, 7,10,2＇, 3 ＇-tetraacetylsuspensolide F （ 4 ）, viburtinoside IV （ 5 ）, viburtinoside II （ 6 ）, viburtinoside B （ 7 ）, luzonoside A （ 8 ）, luzonoside B （ 9 ）, 2a, 3fl,24-trihydroxy-12-ursen-28-oic acid （ 10 ）, 6-hydroxy-20 （ 29 ） -lu- pen-3-one （U）, and pomalic acid （12） based on the their chromatographic properties, chemical and physicochemieal methods, and spectroscopic data. Compound 1 was a new compound and compounds 3-12 were isolated from this plant for the first time. Further- more, we note here the first isolation of compound 2 as a new natural product.