硝酸异山梨酯片联合注射用丹参多酚酸盐对冠心病患者心肌酶谱、炎性因子、血脂及血液流变学指标的影响

Effects of Isosorbide Dinitrate Tablets Combined with Salvianolate Injections on Myocardial Enzyme,Inflammatory Factors and Hemorheology Indicators in Coronary Heart Disease Patients

目的:探讨硝酸异山梨酯联合注射用丹参多酚酸盐对冠心病患者心肌酶谱、炎性因子、血脂及血液流变学指标的影响。方法:选择2015年4月—2016年5月收治的136例患者作为研究对象,按随机数字表法分为观察组和对照组,每组68例。对照组患者给予硝酸异山梨酯片单药治疗,观察组患者在对照组基础上给予注射用丹参多酚酸盐(溶于葡萄糖注射液)静脉滴注。治疗前后分别采集患者外周静脉血,进行心肌酶谱、炎性因子、血脂及血液流变学指标的检测。结果:治疗后,两组患者乳酸脱氢酶、肌酸激酶水平下降程度明显,与治疗前、对照组的差异均有统计学意义(P<0.05)。两组患者肿瘤坏死因子α、白细胞介素18水平下降明显,与治疗前、对照组的差异均有统计学意义(P<0.05)。治疗后,两组患者全血黏度、血浆黏度、全血高切黏度、全血低切黏度较治疗前明显改善,且观察组患者改善程度明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者三酰甘油和高密度脂蛋白胆固醇水平较治疗前明显改善,差异均有统计学意义(P<0.05)。结论:硝酸异山梨酯片联合注射用丹参多酚酸盐治疗冠心病,对患者心肌酶谱、炎性因子、血脂及血液流变学指标均有一定影响,可改善患者预后。

OBJECTIVE：To probe into the effects of Isosorbide dinitrate tablets combined with salvianolate injections on myocardial enzyme, inflammatory factors and hemorheology indicators in coronary heart disease patients. METHODS： 136 patients admitted from Apr. 2015 to May 2016 were extracted to be divided into observation group and control group via the random number table, with 68 cases in each. The control group was treated with Isosorbide dinitrate tablets alone, while the observation group additionally received salvianolate injections （dissolved in 5% Glucose Injection） in intravenous drip. Patients＇ peripheral venous blood were collected to detect the myocardial enzyme, inflammatory factors, blood fat and hemorheology before and after treatment. RESULTS ： After treatment, the LDH and CK levels of two groups decreased significantly, compared with before treatment and the control group, the difference was statistically significant （ P 〈 0.05 ）. Compared with before treatment and the control group, values of TNF-α and IL-18 decreased significantly, the difference was statistically significant（P 〈0. 05）. After treatment, the whole blood viscosity, plasma viscosity, whole high blood viscosity, whole blood low shear viscosity in both groups had been improved significantly, and the observation group was better than the control group, with statistical significance （P 〈 0. 05 ）. After treatment, TG and HDL-C of observation group had been improved significantly compared with before treatment, with statistical significance （P 〈 0. 05 ）. salvianolate injections have effects on myocardial enzyme, heart disease patients to some extent, which can improve CONCLUSIONS： Isosorbide dinitrate tablets combined with inflammatory factors and hemorheology indicators in coronary the prognosis of patients.