促红细胞生成素治疗新生儿缺氧缺血性脑病的疗效观察

Observation on Efficacy of Recombinant Human Erythropoietin in Treatment of Neonatal Hypoxic Ischemic Encephalopathy

目的:探讨促红细胞生成素治疗新生儿缺氧缺血性脑病的临床疗效。方法:选取2015年9月—2016年8月鄂州市妇幼保健院收治的缺氧缺血性脑病患儿66例作为研究对象,以随机数字表法分为观察组和对照组,每组33例。对照组患儿给予常规治疗,观察组患儿在对照组的基础上加用促红细胞生成素治疗。治疗2周后,测定两组患儿的新生儿行为神经评分,比较两组患儿运动发育指数(psychomotor development index,PDI)、智能发育指数(mental development index,MDI)的差异。结果:治疗2周后,观察组患儿的新生儿行为神经评分明显优于对照组,差异有统计学意义(P<0.05);出生第3、6个月时,观察组患儿PDI、MDI指数明显优于对照组,差异均有统计学意义(P<0.05)。结论:促红细胞生成素治疗新生儿缺氧缺血性脑病的疗效显著,可有效促进患儿运动、智力的发育。

OBJECTIVE：To probe into the clinical efficacy of recombinant human erythropoietin in treatment of neonatal hypoxic ischemic encephalopathy. METHODS： 66 patients with neonatal hypoxic ischemic encephalopathy admitted into Ezhou Maternal and Child Health Care Hospital from Sept. 2015 to Aug. 2016 were extracted to be divided into observation group and control group via the random number table, with 33 cases in each. The control group was given conventional treatment, while the observation group additionally received recombinant human erythropoietin based on the control group. After treatment of two weeks, the neonatal behavioral neurological assesssment of two groups were recorded, differences of psychomotor development index （PDI） and mental development index （MDI） of two groups were compared. RESULTS： After treatment of two weeks, the neonatal behavioral neurological assesssment of observation group was significantly better than that of control group, with statistically significant difference （P 〈 0. 05 ）. At the age of three and six months, the PDI and MDI in observation group were better than those in control group, with statistically significant difference （P 〈 0. 05 ）. CONCLUSIONS： The efficacy of recombinant human erythropoietin in treatment of neonatal hypoxic ischemic encephalopathy is remarkable, which can effectively promote the motor ability and intelligence of children.