磷酸肌酸钠改善老年慢性心功能不全患者左心功能的效果观察

Observation on Creatine Phosphate Sodium in Improvement of Left Heart Function on Elderly Patients with Chronic Cardiac Insufficiency

目的:探讨磷酸肌酸钠改善老年心功能不全患者左心功能的疗效。方法:选取老年慢性心功能不全患者286例,采用随机数字表法分为观察组与对照组,每组143例。对照组患者给予常规抗心力衰竭药物治疗,观察组患者在对照组基础上加用磷酸肌酸钠。比较两组患者的临床疗效,左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、血浆氨基末端脑钠肽前体(NT-pro BNP)等指标,以及不良反应发生情况。结果:观察组患者显效率、总有效率分别为61.5%(88/143)、90.9%(130/143),显著高于对照组的44.1%(63/143)、72.0%(103/143),差异均有统计学意义(P<0.05)。治疗后,两组患者LVEF、LVESD、LVEDD与血浆NT-pro BNP等指标均较治疗前显著改善,且观察组患者上述指标改善程度显著优于对照组,差异均有统计学意义(P<0.05)。观察组患者未发生与磷酸肌酸治疗相关的不良反应。结论:在常规治疗基础上加用磷酸肌酸钠,可以显著改善老年慢性心功能不全患者的左心功能,且无严重不良反应。

OBJECTIVE： To evaluate the efficacy of creatine phosphate sodium in improvement of left heart function on elderly patients with chronic cardiac insufficiency. METHODS： 286 elderly patients with chronic cardiac insufficiency were extracted to be divided into observation group and control group via the random number table, with 143 cases in each. The control group was treated with conventional anti-heart failure drugs, while the observation group additionally received creatine phosphate sodium based on the control group. The clinical efficacy, LVEF, LVEDD, LVESD and NT-proBNP and incidence of adverse drug reactions of two groups were compared. RESULTS： The marked effective rate, total effective rate of observation group were respectively 61.5% （88/143） ,90. 9% （ 130/ 143 ）, significantly higher than that of control group [ 44. 1% （ 63/143 ）, 72.0% （ 103/143 ） ], with statistically significant difference（P 〈 0. 05）. After treatment, the LVEF, LVEDD, LVESD and NT-proBNP in two groups had been improved significantly, and the observation group were higher than control group, with statistically significant difference （P 〈 0. 05 ）. There was no adverse drug reactions related to chronic cardiac insufficiency. CONCLUSIONS ： Creatine phosphate sodium combined with conventional treatment can effectively improve left heart function, prognosis and life quality without any severe adverse drug reactions.