胃复春片联合聚普瑞锌颗粒治疗萎缩性胃炎的疗效及对患者细胞炎症因子水平的影响

Efficacy of Weifuchun Tablets Combined with Polaprezine Granules in Treatment of Atrophic Gastritis and Effects on Inflammatory Cytokine Level

目的:探讨胃复春片联合聚普瑞锌颗粒治疗萎缩性胃炎的临床疗效及对患者细胞炎症因子水平的影响。方法:选取2015年6月—2016年6月河源市人民医院/暨南大学附属河源医院收治的萎缩性胃炎患者80例作为研究对象,以随机数字表法分为观察组和对照组,每组40例。对照组患者给予聚普瑞锌颗粒治疗,观察组患者在对照组的基础上加用胃复春片治疗。观察两组患者的临床疗效,比较两组患者治疗前后胃镜评分、慢性炎症病理组织学评分、血清细胞炎症因子水平及不良反应发生情况的差异。结果:观察组患者的总有效率为92.50%(37/40),明显高于对照组的67.50%(27/40),差异有统计学意义(P<0.05)。治疗后,观察组患者胃镜评分、慢性炎症病理组织学评分、肿瘤坏死因子α、白细胞介素6水平明显低于对照组,差异均有统计学意义(P<0.05)。两组患者均未见严重不良反应。结论:胃复春片联合聚普瑞锌颗粒治疗萎缩性胃炎的临床疗效显著,能够降低患者血清肿瘤坏死因子α、白细胞介素6水平,安全性高。

OBJECTIVE：To probe into the clinical efficacy of Weifuchun Tablets combined with Polaprezine Granules in treatment of atrophic gastritis and effects on inflammatory cytokine level. METHODS： 80 patients with atrophic gastritis admitted into Heyuan People＇s Hospital/Heyuan Hospital Affiliated to Jinan University from Jun. 2015 to Jun. 2016 were selected to be divided into observation group and control group via the random number table, with 40 cases in each. The control group was treated with Polaprezine Granules, while the observation group additionally received Weifuchun Tablets based on the control group. The clinical efficacy of two groups were observed, differences of gastroscope score, chronic inflammation pathological histology score, serum cell inflammatory factor level and incidence of adverse drug reactions between two groups were compared before and after treatment. RESULTS ： The total effective rate of observation group was 92.50% （37/40）, significantly higher than that of control group [ 67.50% （ 27/ 40） ] , with statistically significant difference （P 〈 0. 05 ）. After treatment, the gastroscope score, chronic inflammation pathological histology score, TNF-α and IL-6 levels in observation group were significantly lower than those in control group, with Statistically significant difference （P 〈 0. 05 ）. There was no severe adverse drug reactions in both groups. CONCLUSIONS： The clinical efficacy of Weifuchun Tablets combined with Polaprezine Granules in treatment of atrophic gastritis is remarkable, which can reduce the serum TNF- and IL-6 levels with high safety.