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碘对比剂肾损伤的检测方法 被引量:5

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摘要 对比剂肾病是碘对比剂注射后严重的并发症,对其早期及时检测及评价具有重要临床意义。病理诊断虽然可作为诊断肾脏损伤的金标准,但其有创性及次数限制也使其在临床应用有很大局限。目前临床上主要通过测量患者的Scr水平和GFR来判断肾功能,但肌酐变异较大,且对肾功能改变的反应较为滞后。中性粒细胞明胶酶相关载脂蛋白(NGAL)及胱抑制素C(CysC)在肾脏损伤后较早出现升高,已被视为现在已知最可靠的早期预测CIN的生化标志物之一。肾脏功能磁共振(fMRI)无创、无辐射,可重复性与接受性强,对对比剂肾病的早期诊断、指导治疗、判断预后都有较高的价值。本文旨在总结目前临床上对比剂肾病的不同检测方法,为临床选择更恰当的评估对比剂肾损害的方法提供依据。
出处 《放射学实践》 北大核心 2017年第6期643-649,共7页 Radiologic Practice
基金 国家科学自然基金面上项目(81571635) 沈阳市科学技术项目计划(F15-199-1-39)
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