吲哚菁绿荧光成像联合亚甲蓝与纳米炭在乳腺癌前哨淋巴结活检中的对比

Comparison between indocyanine green fluorescence imaging plus methylene blue and plus carbon nanoparticles suspension injection for sentinel lymph node biopsy in breast cancer patients

目的:探讨吲哚菁绿(ICG)荧光成像联合亚甲蓝、纳米炭混悬注射液在乳腺癌前哨淋巴结活检中的差异。方法:选择我院2013年11月至2016年11月收治乳腺癌行前哨淋巴结活检(SLNB)的患者134例,使用ICG联合亚甲蓝者48例,使用纳米炭者86例。结果:ICG联合亚甲蓝组与纳米炭组前哨淋巴结(SLNs)的检出率(P>0.05)、检出数目(P>0.05)、灵敏度(P>0.05)、准确率(P>0.05)、假阴性率(P>0.05)差异无统计学意义;年龄、体质指数(BMI)并不影响两组SLNB的检出率及准确率(均P>0.05)。结论:ICG联合亚甲蓝与纳米炭示踪乳腺癌SLNs具有相同的检出率、检出数目、灵敏度、准确率、假阴性率,并且均操作简便,便于推广实施。

Objective To investigate the differences between indocyanine green （ICG） fluorescence imaging plus methylene blue and plus Carbon Nanoparticles Suspension Injection for sentinel lymph node biopsy （SLNB） in breast cancer patients. Methods A total of 134 cases of early breast cancer patients performed SLNB from November 2013 to November 2016 were involved, of which 48 cases were performed with ICG fluorescence imaging plus methylene blue, and another 86 cases plus Carbon Nanopartieles Suspension Injection. Results There was no significant difference between ICG plus Methylene Blue group and ICG plus nano carbon group in terms of detection rate（P 〉 0.05）, detected numbers （P 〉 0.05） , sensitivity （P 〉 0.05）, accuracy（P 〉 0.05） and false negative rate （P 〉 0.05 ）. Age, and body mass index （BMI） exerted no influence on the detection rate and accuracy of SLNB in two groups （P 〉 0.05 ）. Conclusion ICG Fluorescence Imaging plus Methylene Blue showed similar detection rate, detected numbers, sensitivity, accuracy and false negative rate as it plus Carbon Nanoparticles Suspension Injection for SLNB in breast cancer patients, and both of them can be performed easily and conveniently.