“细胞自噬—细胞因子—伏毒—溃疡性结肠炎”相关性假说

The correlation hypothesis of autophagy-cell factor-Fudu-ulcerative colitis

细胞自噬是广泛存在于真核细胞的一种生理现象,是溶酶体对异常蛋白及细胞器的吞噬降解,同时清除炎症介质和细胞因子,从而成为调节炎症反应的重要途径,是机体一种重要的防御和保护机制,其功能障碍是慢性肠道炎症发病及复发的主要危险因素之一。溃疡性结肠炎(UC)发病机制与遗传、免疫、感染等因素相关,其中免疫调节与UC关系最为密切,而巨噬细胞的功能在免疫调节中充当重要角色。我们认为UC的中医病因可形象地表述为伏毒致病,并提出"细胞自噬—细胞因子—伏毒—UC"相关性假说,为UC的防治提供了新思路。

Autophagy is a common physiological phenomenon in eukaryotic cells. In autophagy, lysosomes engulf and degrade the abnormal protein and organelles as well as clear out inflammatory mediators and cytokines. It is an important way to regulate the inflammatory response and a defense mechanism of the body. Its dysfunction is one of the major risk factors for chronic intestinal inflammation and recurrence. The pathogenesis of ulcerative colitis（UC） is associated with genetic, immune, infection and other factors, among which the immune regulation is the most closely related to UC. The function of macrophages plays an important role in the immune regulation. From the perspective of traditional Chinese medicine, we believe that the cause of UC can be vividly expressed as Fudu, and put forward a correlation hypothesis of ＂autophagy-cell factor-Fudu-UC＂, in the hope of providing a new idea for the prevention and treatment of UC.