性别和经介入治疗的B型急性主动脉夹层患者长期预后的相关性研究

Correlation between gender and long-term prognosis of patients with type B acute aortic dissection after endovascular therapy

目的探究性别和经介入治疗的B型急性主动脉夹层(acute aortic dissection,AAD)患者的长期预后的关系。方法采用回顾性、观察性研究,选取2012年1月—12月所有经介入治疗的B型AAD患者,按性别不同分为男女2组,采用Kaplan-Meier生存曲线分析评估不同性别与累积生存率之间的关系。结果共纳入131例经介入治疗的B型AAD患者,其中男97例(74.0%),女34例(26.0%),中位随访时间2.1年。男性患者的吸烟史、胆固醇、白细胞计数、血红蛋白、肌酐和尿酸均高于女性患者,差异均有统计学意义(P<0.05),其他参数比较差异均无统计学意义(P>0.05)。男性患者院内死亡人数为10例(10.3%),女性患者院内死亡人数为3例(8.8%),两组比较差异无统计学意义(P=0.803)。Kaplan-Meier生存分析表明不同性别的患者在随访期间累积生存率差异无统计学意义(84.5%、82.4%;对数秩检验χ2=0.023,P=0.880)。结论性别和经介入治疗的B型AAD患者中的长期预后无明显相关性。

Objective To explore the correlation between gender and long-term prognosis of patients with type- B acute aortic dissection （AAD） after endovascular therapy （EVT）. Methods From January to December 2012, all patients with type-B AAD undergoing EVT were enrolled by retrospective and observational study. They were divided into male and female groups. Kaplan-Meier analysis was used to analyze the correlation between gender and the cumulative survival rate. Results A total of 131 tyep-B AAD patients who had undergone EVT were selected, including 97 males （74.0%）, and 34 females （26.0%）. The medium follow-up duration was 2.1 years. Smoking history, cholesterol, white blood cell count, hemoglobin, creatinine and uric acid of the patients in males were higher than those in females （P〈0.05）; while the difference in other indexes were not significant （P〉0.05）. The inhospital mortality of male patients was 10 （10.3%）, and was 3 （8.8%） in female patients; there was no significant difference between the two groups （P=0.803）. Kaplan-Meier analysis showed that there was no significant difference in cumulative survival rate between the two groups （84.5% vs. 82.4%; Logrank test χ2=0.023, P=0.880）. Conclusion No correlation between gender and long-term prognosis in patients with type-B AAD after EVT is found.