帕瑞昔布钠超前镇痛用于乳腺癌患者根治术的效果观察

Effects Observation of Preemptive Analgesia of Parecoxib-sodium for Radical Mastectomy of Breast Cancer

目的:探讨帕瑞昔布钠超前镇痛用于对乳腺癌患者根治术的效果。方法:60例择期于全身麻醉下行乳腺癌根治术的女性患者随机分为观察组(40例)和对照组(20例)。麻醉诱导前15 min,观察组患者静脉注射注射用帕瑞昔布钠40 mg;对照组患者静脉注射0.9%氯化钠注射液5 m L。观察两组患者术后不同时间点的疼痛视觉模拟(VAS)评分、静脉自控镇痛(PCA)按压次数及不良反应发生情况。结果:观察组患者术后2、4、6、8 h的VAS评分均显著低于对照组,术后0~4、4~12、12~24、24~36 h的PCA按压次数均显著少于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:帕瑞昔布钠超前镇痛可有效降低乳腺癌患者根治术后的疼痛程度,减少PCA使用次数,且未增加不良反应的发生。

OBJECTIVE： To investigate the effects of preemptive analgesia of parecoxib-sodium for radical mastectomy of breast cancer. METHODS ： A total of 60 female patients underwent selective radical mastectomy of breast cancer under general anesthesia were randomly divided into observation group （40 cases） and control group （20 cases）. 15 min before anesthesia induction, observation group was given intravenous injection of Parecoxib-sodium for injection 40 rag. Control group was given intravenous injection of 0.9% Sodium chloride injection 5 mL. The pain visual analogue scale （VAS）, the frequency of patient controlled intravenous analgesia （PCA） and ADR were observed between 2 groups at different time points after surgery. RESULTS： VAS scores of observation group were significantly lower than those of control group 2,4,6,8 h after operation, and the frequency of PCA 0-4, 4-12, 12-24, 24-36 h after operation was significantly lower than control group, with statistical significance （P〈0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P〉0.05）. CONCLUSIONS： The preemptive analgesia of parecoxib-sodium can effectively reduce pain degree of patients with breast cancer after radical mastectomy, the frequency of PCA, and do not increase the occurrence of ADR.