RNA结合蛋白Sam68及其功能

Functional Roles of the RNA-binding Protein Sam68

细胞通过基因表达调控来应对外界刺激,其中影响mRNA稳定性及翻译效率的转录后调控发挥重要作用。RNA结合蛋白(RNA binding proteins,RBPs)是介导转录后调控的重要分子,Sam68(SRC associated in mitosis of 68 kD)是集信号转导特性与RNA激活功能于一身的RNA结合蛋白,参与转录、可变剪接及核输出等mRNA的代谢过程,且Sam68可通过信号通路参与细胞应答、细胞周期调控和疾病发生等。最新研究表明,Sam68可通过非编码RNAs(noncoding RNA,ncRNAs)参与表观遗传、转录与转录后调控。本文在介绍Sam68结构和转录后修饰的基础上,着重讨论Sam68在信号转导、可变剪接、ncRNAs代谢、疾病发生等方面的最新研究进展。

The cell responses to outside stimuli by altering gene expression,in which post-transcriptional regulations that affect mRNA stability and translation efficiency play an important role.RNA-binding proteins（RBPs） are major regulators in post-transcriptional regulation.SRC associated in mitosis of 68 kD（Sam68） is a RNA-binding protein that induces signal transduction and RNA activation.Sam68 regulates mRNA metabolism such as transcription,alternative splicing and nuclear export.Sam68 also participates in signaling pathways,which are associated with cellular responses to stimuli,cell cycle regulation and tumorigenesis.Recent studies have shown that Sam68-mediated noncoding RNAs（ncRNAs） play important roles in epigenetic,transcriptional and post-transcriptional regulation.In this review,we summarize the molecular structure and post-transcriptional modifications of Sam68 and discuss the role of Sam68 in signal transduction,alternative splicing,ncRNA metabolism and disease development.