角膜交联疗法治疗真菌性角膜疾病的研究进展

Current advance in treatment of fungal keratitis by corneal collagen cross-linking

角膜交联疗法是一种治疗圆锥角膜、角膜扩张及感染性角膜疾病等的光化学疗法。使用370nm波长的紫外线A照射被感光剂核黄素浸润的角膜胶原纤维,诱导角膜胶原纤维发生一系列生物反应。通过阐述这一疗法的基本原理、实验研究、临床应用及相关安全性和副作用问题,提出角膜交联疗法可单独或者联合药物用以治疗真菌性角膜疾病,提高真菌性角膜疾病的治愈率,降低此类疾病并发症及角膜移植手术需求。

Corneal collagen cross- linking （CXL） is a photochemotherapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA at 370nm, was induced to form the crosslinks in corneal stroma. Corneal collagen cross-linking alone or combined with medicine therapy could be used to treat fungal keratitis, improve the cure rates, and reduce the complications and the demands of corneal transplantation surgery. The purpose of this paper is to review the basic principle, procedure, laboratory researches, clinical applications and the safety about this treatment.