癌钙调蛋白在炎症反应促视神经再生作用中的研究进展

Role of inflammation in the relationship between OM and regeneration of optic nerves

癌钙调蛋白(oncomodulin,OM)作为钙结合蛋白的一种,逐渐为我们熟知。近年来有研究证实,OM源于活化的炎症细胞(中性粒细胞),是体内先天免疫系统和神经元之间一种有效的生长促进信号,通过炎症反应诱导的OM是受损视神经轴突再生的关键。OM的促视神经轴突再生作用逐渐成为研究的热点之一。本文就近年来OM作用机制和炎症诱导下OM与视神经再生关系方面的研究和进展做一综述。

Oncomodulin （OM） is known by us progressively as a Calcium binding protein. Recently, OM has been found that it is secreted by inflammatory cells （neutrophilic granulocyte）, and a signal which can promote cell growth between innate immunity and neurons, and a key to regenerate the damaged optical nerves by activating inflammation. The function of promoting the regeneration progress of axons has become a hot issue in recent years. This article summarized the mechanism of OM and the relationship between inflammation- induced OM and optic nerve regeneration research and progress were reviewed.