艾灸对类风湿关节炎炎性损伤修复机制的现代研究进展

Review on Modern Repair Mechanism of Moxibustion for Treating Inflammatory Damage of Rheumatoid Arthritis

类风湿关节炎(RA)是一种慢性炎性反应性疾病,持续的滑膜炎性反应是该病的特征性病理表现。近年来艾灸治疗RA取得了显著的临床疗效,且大量实验研究也表明艾灸对RA炎性损伤具有一定的修复作用。笔者检索了近10年相关实验研究文献并进行整理分析,从糖皮质激素受体、褪黑激素、下丘脑-垂体-肾上腺功能轴、胆碱能神经等中枢层面和局部炎性介质、相关细胞因子及多种炎性细胞信号转导通路等外周层面总结探讨艾灸对RA炎性损伤的修复机制,为今后的研究提供参考依据。

Rheumatoid arthritis （RA） is a chronic inflammatory disease. Persistent inflammation of the synovial membrane is the main characteristic pathological symptom. Moxibustion for treating RA has achieved significant clinical effect in recent years. A large number of experimental studies have also shown that moxibustion promoted the repair of inflammatory damage induced by RA. Based on summarizing 10 years related literatures, the authors analyzed the repair mechanisms of moxibustion for inflammatory damage in RA from central mechanisms including glucocorticoid receptor, melatonine, hypothalamic-pituitary-adrenal axis, and cholinergic nerve to peripheral mechanisms including local inflammatory mediators, cytokine, and inflammatory cell signaling pathway, so as to provide evidences and reference for further research.