肺癌患者外周血HOZOT细胞与放化疗的疗效及预后的相关研究

Studies on the Efficacy and Prognosis of Peripheral Blood HOZOT Cells and Chemotherapies in Patients With Lung Cancer

目的分析肺癌患者外周血HOZOT细胞与放化疗的疗效及预后的关系。方法收集我院2015年10月—2017年1月收治的50例肺癌患者,所有患者均需实施放射治疗和化学治疗。根据放化疗后的临床疗效分为有效组以及对照组。对所有患者均使用ELISA法检测其外周血细胞因子IL-10、1L-8以及RANTES细胞浓度。并使用流式细胞仪检测外周血HOZOT细胞浓度。结果在放化疗后,患者外周血HOZOT细胞和RANTES细胞水平上升,外周血细胞因子IL-10、1L-8下降。所有差异均具有统计学意义(P<0.05)。结论肺癌患者在放化疗后,其外周血HOZOT细胞水平会上升。这提示外周血HOZOT细胞可作为分析肺癌临床疗效和预后的重要方法。

Objective To analyze the effect and prognosis of peripheral blood HOZOT cell in patients with lung cancer. Methods To collect 50 cases of lung cancer in our hospital from October 2015 to January 2017,all patients were treated with radiotherapy and chemotherapy. They were divided into effective groups and control groups according to clinical efficacy ofchemo. The ELISA method was used to detect the concentration of the peripheral blood cell factor IL-10, IL-8 and RANTES cells for all patients. The concentration of peripheral blood HOZOT cells was detected by a fluid cell. Results After the chemo treatment, the patient＇s peripheral blood HOZOT cell and RANTES cell level were significantly increased, and the peripheral blood cell factor IL-10 AND IL -8 had significantly decreased. All the differences were significant （P 〈 0.05）. Conclusion The level of peripheral blood HOZOT cells increased significantly after chemotherapy. This suggests that peripheral blood HOZOT cells can be used as an important method to analyze the clinical efficacy and prognosis of lung cancer.