抑郁症全基因组关联分析的研究进展

The recent advances in genome-wide association studies of depression

抑郁症是一种非常普遍的、可致残的并可中度遗传的精神疾病,严重威胁着人类的健康,给家庭和社会造成了沉重的心理和经济负担。因其发病机制复杂,病因存在显著的多样性,揭示抑郁症的遗传决定因素必然成为抑郁症的有效预防及临床治疗途径。全基因组关联分析(GWAS)目前已经成为研究复杂性状和疾病遗传变异的有效方法。本文主要着眼于有关抑郁症GWAS研究的最新进展,总结目前已知的抑郁症的遗传决定因素,进一步展望抑郁症GWAS研究所面临的挑战及有价值的研究方向,旨在为抑郁症的病因研究以及防治措施提供依据。

Depression,a very prevalent,disabling,and moderately inherited mental illness,is a serious threat to human health,causing serious psychological and economic burden to family and society.The pathogenesis of depression is complex,and the cause is of great diversity.One promising approach to the prevention and clinical treatment of depression lies in uncovering the genetic determinants of the disorder.Genome-wide association studies （GWAS） has become an effective method to study complex traits and genetic variation.Focusing on the findings from GWAS,the review summarizes what is currently known about the genetic determinants of depression,and discusses the challenges and valuable research directions of GWAS on depression,which aim to provide the basis for the etiology study and the prevention and treatment measures of depression.