叶酸受体α在妇科肿瘤临床应用的现状

Folate receptor alpha in clinical application of gynecologic tumor

叶酸受体(FR)是一种富含半胱氨酸的糖基磷脂酰肌醇偶联蛋白,可分为FRα、β及γ3种亚型。其中,FRα于妇科肿瘤中的相关研究,主要集中在抗FRα抗体、FRα介导的成像技术和叶酸偶联药物靶向治疗等方面。随着对这些方面研究的不断深入,FRα作为妇科肿瘤的生物学标志物之一,愈来愈显示出较高的潜在临床价值。笔者拟就FRα在妇科肿瘤临床应用的现状进行阐述。

Folate receptors （FR） are cysteine-rich cell-surface glycoproteins, including FRα, β and γ.FRα is one of the research hotspots.Up to present, the folate depended tumours have been therapeutically and diagnostically exploited by administration of anti-FRα antibodies, FRα-targeted imaging and folate-conjugated drugs and toxins.With the deepening study, FRα as a biological marker of gynecological tumors, shows a high potential clinical value.In this review, we summarize the roles of FRα in clinical application of gynecological tumors.