肿瘤标志物在卵巢癌的研究现状

Current research on tumor markers in ovarian cancer

卵巢癌是女性生殖系统最常见的3大恶性肿瘤之一。在我国卵巢癌导致的患者病死率居于妇科肿瘤首位,严重威胁女性的生命健康。由于卵巢癌早期临床症状隐匿,不易被发现,70%卵巢癌患者被发现时已是卵巢癌晚期。国际妇产科联盟(FIGO)临床分期为Ⅰ期的卵巢癌患者的5年总体生存(OS)率可达90%,而随着病情的进展与加重,或肿瘤复发、转移等因素影响,FIGOⅣ期卵巢癌患者的5年OS率<5%。因此,寻找针对卵巢癌早期诊断及预后评估的高特异度和高敏感度的肿瘤标志物,成为卵巢癌研究的热点。卵巢癌早期诊断及预后评估,可提高卵巢癌患者的OS率和临床治疗疗效。

Ovarian cancer is one of the most common malignancies in female reproductive system and threatens seriously the health of women, which results in the highest mortality rate among gynecological tumors in China.Because the clinical symptoms in the early stage of ovarian cancer is insidious and can not easily be found, 70% of the ovarian cancer cases have developed into advanced stage when they are diagnosed as ovarian cancer.In the ovarian carcinoma patients, five-year overall survival （OS） rate of Federation International of Gynecology and Obstetrics （FIGO） Ⅰ can achieve 90%, while with the development of this disease, invading or relapsing, OS rate of FIGO Ⅳ ovarian cancer is less than 5%.Therefore, it′s becoming a research hotspot of ovarian cancer to seek for the tumor markers which are of high specificity and sensitivity to help the early diagnosis and prognosis evaluation of ovarian cancer.Early diagnosis and prognosis evaluation can improve the OS rate and clinical curative effect in ovarian cancer patients.