CO_2激光治疗有症状宫颈糜烂合并高危型人乳头瘤病毒感染

CO_2 laser treatment for cervical erosion patients with high risk human papilloma virus infection and clinical symptoms

目的探讨CO_2激光治疗有症状宫颈糜烂合并高危型人乳头瘤病毒(HR-HPV)感染的有效性。方法选择2015年1至12月,在扬州市妇幼保健院采用CO_2激光治疗的宫颈糜烂合并HR-HPV感染,并且伴临床症状或体征的48例宫颈糜烂患者为研究对象。统计学分析轻、中度有症状宫颈糜烂合并HR-HPV感染患者与重度有症状宫颈糜烂合并HR-HPV感染患者的治疗有效率,了解48例患者经CO_2激光治疗后的人乳头瘤病毒(HPV)转阴率。结果 CO_2激光治疗后,27例轻、中度有症状宫颈糜烂合并HR-HPV感染患者的治疗有效率为96.3%(26/27),21例重度有症状宫颈糜烂合并HR-HPV感染患者的治疗有效率为90.5%(19/21),二者比较,差异无统计学意义(χ~2=0.050,P=0.823)。48例患者术后3~6个月复查HPV-DNA,其中45例为HPV呈阴性,3例仍然呈阳性,术后HPV转阴率为93.8%(45/48)。结论 CO_2激光治疗是临床治疗有症状宫颈糜烂合并HR-HPV感染的有效治疗方法。

Objective To investigate the effects of CO2 laser treatment for cervical erosion patients with high risk human papilloma virus（HR-HPV） infection and clinical manifestations.Methods From January to December 2015, 48 cervical erosion patients with HR-HPV infection combined with clinical symptoms or signs who received CO2 laser treatment in Yangzhou Maternal and Child Care Service Centre were chosen as research subjects.The difference of effective rates between cervical erosion level of mild/moderate and severe was compared.Understand the human papilloma virus （HPV） turn negative rate of the 48 patients after treatment.Results After CO2 laser treatment, the treatment effective rate of 27 cases of mild/moderate cervical erosion patients was 96.3% （26/27）, the treatment effective rate of 21 cases of severe cervical erosion patients was 90.5%（19/21）, there was no significant difference between two effective rates （χ2=0.050, P=0.823）.The HPV-DNA recheck results after 3-6 months of operation of 48 patients, 45 cases turned to negative and 3 cases still remained positive.The turn negative rate of HPV was 93.8%（45/48） after operation.Conclusions CO2 laser treatment is an effective method for the treatment of cervical erosion patients with HR-HPV infection combine with clinical manifestations.