急性缺血性脑卒中患者早期神经功能恶化的影响因素研究

Risk factors of early neurological deterioration in patients with acute ischemic stroke

目的探讨急性缺血性脑卒中患者发生早期神经功能恶化(END)的危险因素。方法收集148例急性缺血性脑卒中患者的临床资料,根据患者是否发生早期神经功能恶化分为END组和非END组,通过logistic回归分析筛选出患者发生早期神经功能恶化的危险因素。结果 148例急性缺血性脑卒中患者中,出现END 39例,未出现END109例。logistic逐步回归分析结果显示,高血压、糖尿病、心房颤动、颈动脉狭窄以及高NIHSS评分是缺血性脑卒中患者发生早期神经功能恶化的危险因素(P<0.05)。结论高血压、糖尿病、心房颤动、颈动脉狭窄以及高NIHSS评分是缺血性脑卒中患者发生早期神经功能恶化的危险因素,及时发现并给予有效干预可有效降低患者END的发生率、致残率及病死率。

Objective To explore the risk factors of early neurological deterioration （END） in patients with acute ischemic stroke. Methods The clinical data of 148 patients with acute ischemic stroke was collected, and 148 patients were divided into early neurological deterioration group （END group） and non early neurological deterioration group （non END group） according to whether with early neurological deterioration, the risk factors of early neurological deterioration in patients with acute ischemic stroke were analyzed by logistic stepwise regression analysis. Results Among 148 patients with acute ischemic stroke, there were 39 cases occurred END, and 109 cases did not. The logistic regression analysis showed that hypertension, diabetes, atrial fibrillation, carotid artery stenosis and high NIHSS score were the risk factors of early neurological deterioration in acute ischemic stroke （P 〈 0.05 ）. Conclusions Hypertension, diabetes, atrial fibrillation, carotid artery stenosis and high NIHSS score are the risk factors of early neurological deterioration in acute isehemic stroke, timely discovery and effective intervention can reduce the occurrence rate, disability rate and mortality of END.