摘要
细胞凋亡在生物体的生理和病理过程中起关键作用.在体检测凋亡对神经退行性病变、肿瘤等凋亡相关疾病的检测、治疗及预后评价起着重要作用.以凋亡细胞发生发展中的特征变化为靶点的核医学分子影像技术可以探测凋亡的位置、程度及其与治疗的相关性,从而指导临床诊疗.本文综述了针对不同凋亡靶点的蛋白质、多肽及小分子类凋亡显像剂的研究进展.
Apoptosis plays a crucial role in various physiology and pathologic processes of organisms.The non-invasive imaging of apoptosis may have potentially important diagnostic and prognostic predictive values on apoptosis-associated diseases, such as neurodegenerative diseases and neoplasms.Molecular imaging of nuclear medicine provides a useful tool to investigate these features in vivo by using suitable radiopharmaceuticals.This review summarizes the recent advances in imaging agents targeting the apoptosis process.
出处
《中华核医学与分子影像杂志》
北大核心
2017年第6期366-369,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
国家自然科学基金（81371593）
