首诊肺癌住院患者特征分析

Characteristics analysis of inpatients primary diagnosed with lung cancer

目的 分析首诊肺癌患者在性别、年龄、吸烟、病理类型及基因检测情况等方面的特征.方法 收集整理1 224 例首诊肺癌患者的临床资料并进行统计学分析.结果 肺癌病理类型构成比,腺癌（52.04%）〉鳞癌（41.67%）〉小细胞肺癌（3.92%）〉腺鳞（1.80%）〉其他（0.57%）.男性肺癌患者多于女性,性别比例为1.82：1,性别差异最大的是鳞癌,男女比例为5：1;差异最小的是腺癌,男女比例为1.03：1.肺癌的年龄段分布情况：≥60岁患者658例（53.76%）、40-60岁患者550例（44.93%）、≤40岁患者16例（13.07%）.男性的吸烟率高于女性,其中鳞癌最高,小细胞癌次之,女性鳞癌的吸烟率亦较高.腺癌及腺鳞混合癌的基因检测率为24.89%,其中检测患者的敏感突变率为24.39%.结论 首诊肺癌患者发病特点为男性多于女性、发病年龄段主要分布在60岁及以上患者,其中主要病理类型为腺癌,而基因检测率相对较低,有待进一步提高,以指导分子靶向药物的治疗.

Objective To analyze the features of age,smoking,pathological types and genetic testing conditions of primary lung cancer patients.Methods The clinical data of 1 224 cases of lung cancer were sellected and evaluated.Results Pathological type composition of lung cancer,adenocarcinoma （52.04%） 〉 squamous cell carcinomas （41.67%） 〉 small cell lung cancer （3.92%） 〉 gland scale （1.80%） 〉 other （0.57%）.Lung cancer cases in male were more than those in female.The proportion of male and female was 5：1 in squamous cell carcinomas and 1.03：1 in adenocarcinoma.The age distribution of lung cancer,658 patients （53.76%） were more than or equal to 60 years of age,550 patients （44.93%） were between 40 to 60 years of age,16 patients （13.07%） were less than 40 years old.The smoking rate of the male was higher than that of the female,and the squamous cell carcinomas as the highest in the cases.The gene detection rate of adenocarcinoma and gland scale cancer was 24.89%,the sensitive mutation rate was 24.39%.Conclusions Characteristics of inpatients with primary diagnosed lung cancer is men more than women,the age of onset is mainly distributed in patients aged 60 years and above,the main pathological type is adenocarcinoma,and gene detection rate is relatively low,remains to be further improved,as to guide the treatment of molecular targeted drugs.