参芪扶正注射液辅助治疗中晚期胃肠道恶性肿瘤的疗效及安全性评价

Efficacy and safety of Shenqi Fuzheng injection auxiliary in treatment of middle-late gastrointestinal malignant tumor

目的 探讨参芪扶正注射液辅助治疗中晚期胃肠道恶性肿瘤的疗效及安全性.方法 选取2013年12月至2016年1月符合研究选取标准的86例中晚期胃肠道恶性肿瘤疾病患者,根据入院先后顺序分为研究组43例与对照组43例.对照组仅采用化疗治疗,研究组采用参芪扶正注射液辅助化疗方案治疗.统计两组临床疗效、不良反应发生率,并对比治疗前后两组生活质量评分、抑郁及焦虑评分变化情况.结果 研究组治疗总有效率为55.82%,对照组为32.56%,两组比较差异有统计学意义（P〈0.05）.治疗前两组精神状态、生理功能、社会功能、情感职能、抑郁及焦虑评分比较差异未见统计学意义（P〉0.05）;治疗后,两组各项指标均较治疗前有所改善,且研究组明显优于对照组,差异有统计学意义（P〈0.05）.研究组不良反应发生率为23.25%,对照组为48.83%,两组比较差异有统计学意义（P〈0.05）.结论 参芪扶正注射液辅助治疗中晚期胃肠道恶性肿瘤疗效确切,可有效减轻不良反应,提高临床疗效,缓解患者抑郁及焦虑状态,改善其生活质量.

Objective To investigate the efficacy and safety of Shenqi Fuzheng injection auxiliary in treatment of middle-late gastrointestinal malignant tumor.Methods Eighty-six patients with advanced gastrointestinal cancer were selected to receive the study from December 2013 to January 2016,according to the order of admission,they were divided into study group （n=43） and control group （n=43）.The control group was treated by chemotherapy only,the study group was treated with the adjuvant chemotherapy of Shenqi Fuzheng injection.The clinical efficacy and adverse reaction rate of the two groups were statistically analyzed,and the changes of scores of quality of life,depression and anxiety before and after treatment were compared between the two groups.Results The total effective rate was 55.82% in the study group and 32.56% in the control group,and there was significant difference between the two groups （P〈0.05）.There was no significant difference in the mental state,physical function,social function,emotional function,depression and anxiety between the two groups before treatment （P〉0.05）;after treatment,the two groups of indicators were better than before treatment,and the study group was significantly better than the control group,the difference was significant （P〈0.05）.The incidence rate of adverse reactions was 23.25% in the study group and 48.83% in the control group,and there was significant difference between the two groups （P〈0.05）.Conclusions Shenqi Fuzheng injection auxiliary is on effective middle-late gastrointestinal malignant tumor,which can effectively reduce the toxic and side effects,improve the clinical efficacy,relieve depression and anxiety of patients,improve the quality of life.