脑心通胶囊对高原习服青年体力作业能力的影响

Effect of Naoxintong capsule on physical activities in altitude acclimatized youth

目的:观察脑心通胶囊对高原习服青年体力作业能力的影响。方法:在海拔4 300 m,选择40名已习服高原的男性青年,采取双盲、安慰剂对照的方法随机将受试者分为脑心通组和安慰剂组,每组20例。脑心通组服用步长脑心通胶囊,1.6g(4粒)/次,2/d,连续服药15d;安慰剂组服用安慰剂(面粉胶囊),服用时间与剂量同脑心通组。于服药前、后分别测定安静时和运动后的心率、血氧饱和度(SaO_2)、身体做功能力(PWC170)、最大吸氧量(VO2max)等体能指标;并采血检测血乳酸(LA)、血糖(Glu)、丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)及一氧化氮合酶(NOS)的含量。结果:脑心通组服药后较服药前安静时SaO_2、一级负荷SaO_2及PWC170增加,差异显著(P<0.05);安慰剂组服药前运动后及服药后运动后较安静时LA、MDA升高,NOS降低,有显著差异(P<0.05或P<0.01);脑心通组服药前运动后较安静时NOS降低,LA、MDA升高,服药后运动后较安静时Glu升高,NOS降低,有显著差异(P<0.05);脑心通组服药后较服药前Glu、NOS升高,LA、MDA降低,有显著差异(P<0.05或P<0.01);脑心通组较安慰剂组服药后Glu、NOS增高,LA、MDA降低,有显著差异(P<0.05)。其他指标无统计学差异(P>0.05)。结论:脑心通胶囊能提高高原机体SaO_2,改善运动时能量代谢,延缓运动性疲劳的产生,提高机体活动能力。

Objective：To observe the effect of Naoxintong capsule（NXT）on physical activities in altitude acclimatized youth.Methods：A double-blind,placebo-controlled randomized trail was performed at an altitude of 4 300 m,40 young men who got acclimatized to high altitude were recruited.The subjects were randomly and equally divided into NXT experimental group and the placebo group.The subjects in NXT group was treated with Buchang Naoxintong capsule 1.6g（4capsules）twice per day for 15 days,and the control group were given placebo（flour capsules）.The data of physical fitness indicators were collected before and after the treatments.The data inclued heart rate,SaO2,PWC170,VO2 max when the subjects at rest and after loading exercises.Each subject underwent a blood test to detect the lever of blood lactate（LA）,glucose（Glu）,malondialdehyde（MDA）,superoxide dismutase（SOD）,nitric oxide（NO）and nitric oxide synthase（NOS）when they at fasting and resting 5 minutes after exercises.Results：SaO2,SaO2 at the first load and PWC170 significantly incresed in the NXT group after the treatment,compared with they before taking the medicine（P〈0.05）.LA and MDA in the control group significantly increased and NOS reduced after exercises,compared with those at rest,both before and after the treatment（P〈0.05 or P〈0.01）.NOS in the NXT group significantly decreased after taking exercises than at rest,LA and MDA increased before taking the medicine and Glu increased after taking the medicine（P〈0.05）.After taking the medicine the experimental group Glu and NOS significantly increased,LA and MDA reduced（P〈0.05 or P〈0.01）.The other indicators showed no statistical difference（P 〉0.05）.Conclusion：Naoxintong capsule can improve SaO2 and energy metabolism during exercise in the altitude acclimatized youth,delay the process of sports fatigue,and increase their physical activities.