肺动脉置管灌注r-PA治疗肺动脉栓塞的疗效观察

Curative effect of pulmonary artery catheter perfusion r-PA on pulmonary embolism

目的:观察重组人组织型纤溶酶原激酶衍生物(瑞通立r-PA)肺动脉灌注治疗肺动脉栓塞的疗效及安全性。方法:在数字减影血管造影(DSA)下采用瑞通立肺动脉置管灌注治疗肺动脉栓塞26例,观察处理前后肺动脉压、动脉血氧分压、收缩压变化。结果:26例患者术前肺动脉压、动脉血氧分压和收缩压分别为(64.45±7.62)、(75.38±15.87)、(86.53±12.87)mmHg;术后分别为(26.13±9.26)、(90.43±9.27)、(112.73±13.81)mmHg,治疗前后比较均有统计学差异(P<0.01)。结论:瑞通立溶栓可快速缓解肺动脉栓塞临床症状,是一种疗效肯定且安全的方法。

Objective：To observe the efficacy and safety of original human recombinant tissue type fibrinolytic enzyme kinase derivatives（r-PA）pulmonary perfusion in the treatment of pulmonary embolism.Methods：Twenty-six cases of pulmonary embolism were treated with r-PA pulmonary artery catheter perfusion under DSA,pulmonary artery pressure,arterial partial pressure of oxygen and systolic pressure were observed before and after treatment.Results：Twenty-six patients preoperative pulmonary artery pressure,arterial partial pressure of oxygen and systolic pressure were（64.45±7.62）mmHg,（75.38±15.87）mmHg,（86.53±12.87）mmHg.Postoperative respectively（26.13±9.26）mmHg,（90.43±9.27）mmHg,（112.73±13.81）mmHg,there were statistically differences between two groups（P〈0.01）.Conclusion：R-PA thrombolysis can quickly relieve the clinical symptoms of pulmonary embolism,and it is an effective and safe therapy.