不同麻醉药物对老年患者术后的影响

Effects of different anesthetic drugs on cognitive function,cerebral oxygen metabolism and neurological function in elderly patients

目的研究不同麻醉药物对老年患者术后的影响。方法选取2015年10月-2016年10月该院收治的94例行全身麻醉手术的老年患者,根据患者入院顺序均分为观察组和对照组。观察组的麻醉药物为依托咪酯,对照组使用丙泊酚。比较两组患者手术前和手术后3 d认知功能、脑部氧代谢及血清神经功能的改善情况。结果术后3 d,观察组的简易精神状态评价量表评分高于对照组。观察组的人神经特异性烯醇化酶指标低于对照组,人脑源性神经营养因子、人胰岛素样生长因子1、转化生长因子β1指标高于对照组。结论在老年患者中使用依托咪酯进行麻醉,能有效改善患者认知功能,降低脑氧代谢,对患者大脑发挥保护作用。

Objective To study the effects of different anesthetic drugs on elderly patients. Methods From October 2015 to October 2016, 94 elderly patients undergoing general anesthesia were enrolled. According to the order of admission, the patients were divided into observation group and control group. The observation group was given Etomidate, and the control group was given Propofol. The cognitive function, brain oxygen metabolism and serum neurological improvement were compared between the two groups before operation and 3 days after operation. Results On the 3rd day after operation, the Mini Mental State Examination （MMSE） score of the observation group was significantly higher than that of the control group （P 〈 0.05）. The neuron specific enolase of the observation group was significantly lower than that of the control group （P 〈 0.05）. The brain-derived neurotrophic factor, insulin-like growth factor 1 and transforming growth factor-β1 in the observation group were significantly higher than those in the control group （P〈 0.05）. Conclusions Etomidate anesthesia in elderly patients can effectively improve the cognitive function of patients, reduce cerebral oxygen metabolism, and play protective effect on patient＇s brain.