LH联合羟基喜树碱治疗肝癌合并肝硬化的近期疗效研究

Clinical effect of laparoscopic hepatectomy combined with Hydroxycamptothecin on liver cancer with liver cirrhosis

目的观察腹腔镜下肝切除术(LH)联合羟基喜树碱治疗肝癌合并肝硬化患者的近期疗效。方法选取2013年10月-2015年3月于承德医学院附属医院住院治疗的肝癌合并肝硬化患者76例,所有患者均先行LH,术后第4周连续7 d静脉滴注4~6 mg羟基喜树碱予以化疗,3周计为1个疗程。4个疗程后定期随访观察患者黄疸、腹胀等临床症状的改善情况,采用Karnofsky评分法对患者近期生活质量进行评价。结果近期随访12个月时,治疗有效率为88.16%。临床症状评分及Karnofsky评分显示,所有患者病情好转,临床症状改善,生活质量提高,术后化疗毒副反应轻微,均可耐受。结论 LH联合羟基喜树碱治疗肝癌合并肝硬化患者的近期疗效好,能够有效改善患者的临床症状,提升患者的生存质量。

Objective To observe the short-term effect of laparoscopic hepatectomy combined with Hydroxycamptothecin （HCPT） on liver cancer with liver cirrhosis. Methods Seventy-six patients of liver cancer with liver cirrhosis were selected from our hospital between October 2013 and March 2015. All the patients underwent laparoscopic liver resection. In the 4th week after surgery, they received intravenous drip of 4-6 mg HCPT for chemotherapy for continuous 7 d, 3 weeks for 1 course. After 4 courses, regular follow-up was carried out to observe the improvement of clinical symptoms such as jaundice, abdominal distension and other clinical symptoms. Kamofsky scoring method was used to evaluate the quality of life of patients in the near future, and SPSS 22.0 software was applied to statistically analyze the research data. Results In the 12-month follow-up, the effective rate was 88.16%. Clinical symptom score and Karnofsky score showed that the condition of all patients was obviously controlled, the clinical symptoms were significantly improved, the quality of life was markedly improved, the postoperative side effects of chemotherapy were mild and tolerable. Conclusions Laparoscopie hepatectomy combined with HCPT treatment has good effect on hepatocellular carcinoma combined with cirrhosis, can effectively improve the clinical symptoms of the patients and improve their quality of life.