雷贝拉唑钠肠溶片治疗老年浅表性胃炎的临床研究

Clinical trial of rabeprazole sodium enteric-coated tablets in the treatment of elderly patients with superficial gastritis

目的观察雷贝拉唑肠溶片联合阿莫西林胶囊和克拉霉素片治疗老年浅表性胃炎的临床疗效及安全性。方法将66例老年浅表性胃炎患者随机分为对照组33例与试验组33例。2组患者均予以克拉霉素每次500 mg,bid,口服+阿莫西林每次20 mg,bid,口服,连续用药14 d。在此基础上,对照组予以奥美拉唑肠溶片每次20 mg,bid,口服,连续用药28 d;试验组予以雷贝拉唑钠肠溶片每次20 mg,bid,口服,连续用药28 d。比较2组患者的临床疗效、血清胃泌素、超氧岐化酶活力、丙二醛,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为90.91%(30/33例)和69.70%(23/33例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的血清胃泌素分别为(62.00±6.50),(83.48±9.17)pg·L^(^(-1));超氧岐化酶活力分别为(101.42±11.05),(95.33±10.07)U·m L^(^(-1));丙二醛分别为(4.49±0.61),(5.00±0.64)μmol·L^(^(-1)),差异均有统计学意义(均P<0.05)。试验组的药物不良反应主要有胃肠道不适、乏力、头痛,对照组的药物不良反应主要有胃肠道不适、转氨酶升高、意识模糊、失眠。试验组和对照组的药物不良反应发生率分别为9.09%和15.15%,差异无统计学意义(P>0.05)。结论雷贝拉唑肠溶片联合阿莫西林胶囊和克拉霉素片治疗老年浅表性胃炎的临床疗效显著,且不增加药物不良反应的发生率。

Objective To observe the clinical efficacy and safety of rabeprazole sodium enteric-coated tablets combined with amoxicillin capsules and clarithromycin tablets in the treatment of elderly with superficial gastritis.Methods A total of 66 cases with elderly superficial gastritis were randomly divided into control group and treatment group with 33 cases per group.Two groups were treated with clarithromycin 500 mg bid oral and amoxicillin 20 mg bid oral for 14 days.On the basis,control group was given omeprazole enteric-coated tablets 20 mg bid oral for 28 d,while the treatment group was given rabeprazole enteric-coated tablets 20 mg bid oral for 28 d.The clinical efficacy,serum gastrin,superoxide dismutase（SOD）,malondialdehyde（MDA） and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were90.91%（30/33 cases） and 69.70%（23/33 cases） with significant difference（P 〈 0.05）.After treatment,the main indexes in treatment and control groups were compared： serum gastrin were（62.00 ± 6.50）,（83.48 ± 9.17） pg·L-1; SOD were（101.42 ± 11.05）,（95.33 ± 10.07） U·m L-1; MDA were（4.49 ± 0.61）,（5.00 ± 0.64） μmol·L-1,with significant differences（P 〈 0.05）.The adverse drug reactions in treatment group were based on gastrointestinal discomfort,fatigue and headache,which in control group were gastrointestinal discomfort,elevated aminotransferase,awareness and insomnia.The incidences of adverse drug reactions in treatment and control groups were 9.09% and 15.15%,without significant difference（P 〉 0.05）.Conclusion Rabeprazole sodium enteric-coated tablets combined with amoxicillin capsules and clarithromycin tablets has a definitive clinical efficacy in the treatment of elderly with superficial gastritis,without increasing the incidence of adverse drug reactions.