褪黑激素影响损伤微环境中干细胞活性的研究进展

Progress on the effects of melatonin on the activity of stem cells in the micro environment of injury

干细胞可用于修复组织器官损伤。但是,干细胞移植后,存活率较低成为其临床推广应用的弊端。褪黑激素是一种具有多种生理功能的神经内分泌激素,能够影响干细胞的增殖和分化,而且能够显著提高干细胞移植后的存活率。本文就褪黑激素对损伤微环境中干细胞活性的影响做一综述,为褪黑激素联合干细胞修复组织器官损伤提供参考。

In recent years,studies have shown that stem cells can be used to repair tissue and organ damage,but the lowly survival rate of stem cell transplantation has become a disadvantage of clinical application.Melatonin is a kind of neuroendocrine hormone that has many physiological functions,and an increasing number of researches have shown that it not only can affect stem cell proliferation and differentiation,but also can significantly improve the survival rate of stem cell transplantation.Therefore,in order to provide reference resources for repairing tissue and organ damage by using melatonin and stem cell,the effects of melatonin on the activity of stem cells in the microenvironment of injury were reviewed.