有机阴离子转运多肽1B1转录及蛋白表达调控机制的研究现状

Research status of organic anion transport polypeptide 1B1 in transcription and protein expression regulation mechanism

有机阴离子转运多肽1B1(OATP1B1)属于溶质转运体(SLC)超家族,主要负责将内、外源物质转运至肝细胞代谢。本文描述了相关核受体和核因子-κB通路对OATP1B1 mRNA和蛋白表达的调控作用,旨在指导临床合理用药、预测药物相互作用、减少药物不良反应。

Organic anion transport polypeptide 1B1（OATP1B1） belongs to the solute carrier（SLC） superfamily,which is mainly responsible for the transfer of internal and external substances into liver cells for metabolism.This review describes the regulation of related nuclear receptors and nuclear factor-kappa B pathway on OATP1B1 mRNA and protein expression in order to guide rational drugs use,predict drug-drug interactions,and reduce adverse drug reactions.