农村中老年人群高甘油三酯腰围与2型糖尿病的患病率及关联性分析

Prevalence and relationship between hypertriglyceridemia-waist and type 2 diabetes mellitus among middle-aged and elderly residents in rural area

目的:分析农村中老年人群高甘油三酯腰围(HTGW)、2型糖尿病(T2DM)的流行现状及两者间的关联。方法:采用整群抽样的方法于2013年和2014年的7~8月对河南某农村地区45~75岁的中老年人群进行横断面调查,收集其人口统计学特征、行为危险因素、人体测量指标和空腹血标本,并进行血糖和脂质谱的检测。结果:共纳入10 218名研究对象,其中男性3 836人(37.54%),中位年龄56.62岁。HTGW共2 845人(27.84%),男性646人(16.84%),女性2 199人(34.46%)。T2DM共1 406人(13.76%),男性469人(12.23%),女性937人(14.68%)。在调整了年龄、血压、吸烟、饮酒、家族史、体力活动、体重指数(BMI)、高密度脂蛋白后,logistic回归分析结果显示与腰围和甘油三酯水平均正常的人群相比,HTGW可增加T2DM的发病风险,其OR(95%CI)为3.810(3.050~4.760)。以性别和BMI为分层变量分析发现,HTGW与T2DM的关联女性高于男性、18.5≤BMI<24.0kg/m^2人群高于24.0≤BMI<28.0 kg/m^2人群。结论:该农村地区中老年人群HTGW和T2DM的患病率较高,HTGW是T2DM稳定的危险因素。

Aim： To assess the prevalence and relationship between hypertriglyceridemia-waist（ HTGW） and type 2diabetes mellitus（ T2DM） among middle-aged and elderly residents in the rural area of Henan Province. Methods： A population-based cross-sectional study was conducted in middle-aged and elderly residents aged 45 to 75 years in a rural area of Henan Province from July to August of 2013 and 2014. Demographic characteristics,behavioral risk factors and biochemical indexes were collected in this study. Results： Among the 10 218 subjects,3 836（ 37. 54%） were males,and the median age was 56. 62 years. There were 2 845 cases（ 27. 84%） of HTGW（ male 16. 84%,female 34. 46%） and 1 406 cases（ 13. 76%） of T2DM（ male 12. 23%,female 14. 68%）. After adjusting age,blood pressure,smoking,drinking alcohol,family history,manual labor,BMI and high density lipoprotein,the results of logistic regression analysis showed that,HTGW was the risk factor of T2DM [OR（ 95% CI） = 3. 810（ 3. 050-4. 760） ]. Stratification analysis according to gender and BMI showed that the association was stronger in females than in males,in 18. 5≤BMI 〈 24. 0 kg/m2 residents than in 24. 0 ≤BMI 〈 28. 0 kg/m2 residents. Conclusion： Among the rural middle-aged and elderly residents,the prevalences of HTGW and T2DM are relatively high,and HTGW is stably and significantly associated with risk of T2DM.